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(American Journal of Pathology. 2005;167:437-453.)
© 2005 American Society for Investigative Pathology

Changes in Interstitial Cells of Cajal at the Deep Muscular Plexus Are Associated with Loss of Distention-Induced Burst-Type Muscle Activity in Mice Infected by Trichinella spiralis

Xuan-Yu Wang*, Maria-Giuliana Vannucchi{dagger}, Florentine Nieuwmeyer*, Jing Ye*, Maria-Simonetta Faussone-Pellegrini{dagger} and Jan Dirk Huizinga*

From the Intestinal Disease Research Program and Department of Medicine,* McMaster University, Hamilton, Ontario, Canada; and the Department of Anatomy, Histology, and Forensic Medicine,{dagger} University of Florence, Florence, Italy

The physiology and pathophysiology of the network of interstitial cells of Cajal associated with the deep muscular plexus (ICC-DMP) of the small intestine are still poorly understood. The objectives of the present study were to evaluate the effects of inflammation associated with Trichinella spiralis infection on the ICC-DMP and to correlate loss of function with structural changes in these cells and associated structures. We used immunohistochemistry, electron microscopy, and assessment of distention-inducing electrophysiological parameters in vitro. Damage to ICC-DMP was associated with a loss of distention-induced patterns of electrical activity normally associated with distention-induced peristalsis. Consistently, the timing of recovery of ICC-DMP paralleled the timing of recovery of the distention-induced activity. Nerve varicosities associated with ICC-DMP including cholinergic nerves, assessed by immunoelectron microscopy and whole mount double labeling, paralleled injury to ICC-DMP thus contributing to impaired excitatory innervation of smooth muscle cells. Major additional changes included a remodeling of the inner circular muscle layer, which may affect long-term sensitivity to distention after infection. In conclusion, transient injury to ICC-DMP in response to T. spiralis infection is severe and associated with a complete lack of distention-induced burst-type muscle activity.




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F. Nieuwmeyer, J. Ye, and J. D. Huizinga
Ava[L-Pro9,N-MeLeu10] Substance P(7-11) (GR 73632) and Sar9, Met(O2)11 Increase Distention-Induced Peristalsis through Activation of Neurokinin-1 Receptors on Smooth Muscle and Interstitial Cells of Cajal
J. Pharmacol. Exp. Ther., April 1, 2006; 317(1): 439 - 445.
[Abstract] [Full Text] [PDF]


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