help button home button Am J Pathol ASIP 2008 Summer Academy, Molecular Methcanisms of Human Disease: Injury, Inflammation, and Tissue Repair
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mäki, J. M.
Right arrow Articles by Myllyharju, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mäki, J. M.
Right arrow Articles by Myllyharju, J.
(American Journal of Pathology. 2005;167:927-936.)
© 2005 American Society for Investigative Pathology

Lysyl Oxidase Is Essential for Normal Development and Function of the Respiratory System and for the Integrity of Elastic and Collagen Fibers in Various Tissues

Joni M. Mäki*{dagger}, Raija Sormunen{dagger}{ddagger}, Sari Lippo*{dagger}, Riitta Kaarteenaho-Wiik{ddagger}§, Raija Soininen{dagger} and Johanna Myllyharju*{dagger}

From the Department of Medical Biochemistry and Molecular Biology,* Collagen Research Unit, Biocenter Oulu,{dagger} and the Departments of Pathology{ddagger} and Internal Medicine,§ Oulu University Hospital, University of Oulu, Oulu, Finland

Lysyl oxidases, a family comprising LOX and four LOX-like enzymes, catalyze crosslinking of elastin and collagens. Mouse Lox was recently shown to be crucial for development of the cardiovascular system because null mice died perinatally of aortic aneurysms and cardiovascular dysfunction. We show here that Lox is also essential for development of the respiratory system and the integrity of elastic and collagen fibers in the lungs and skin. The lungs of E18.5 Lox–/– embryos showed impaired development of the distal and proximal airways. Elastic fibers in E18.5 Lox–/– lungs were markedly less intensely stained and more disperse than in the wild type, especially in the mesenchyme surrounding the distal airways, bronchioles, bronchi, and trachea, and were fragmented in pulmonary arterial walls. The organization of individual collagen fibers into tight bundles was likewise abnormal. Similar elastic and collagen fiber abnormalities were seen in the skin. Lysyl oxidase activity in cultured Lox–/– skin fibroblasts and aortic smooth muscle cells was reduced by ~80%, indicating that Lox is the main isoenzyme in these cells. LOX abnormalities may thus be critical for the pathogenesis of several common diseases, including pulmonary, skin, and cardiovascular disorders.





This article has been cited by other articles:


Home page
Cardiovasc ResHome page
C. Rodriguez, J. Martinez-Gonzalez, B. Raposo, J. F. Alcudia, A. Guadall, and L. Badimon
Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseases
Cardiovasc Res, July 1, 2008; 79(1): 7 - 13.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. D. Bland, R. Ertsey, L. M. Mokres, L. Xu, B. E. Jacobson, S. Jiang, C. M. Alvira, M. Rabinovitch, E. S. Shinwell, and A. Dixit
Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice.: Prelude to defective alveolar septation during lung development?
Am J Physiol Lung Cell Mol Physiol, January 1, 2008; 294(1): L3 - L14.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
M.-S. Tsai, S.-M. Hwang, K.-D. Chen, Y.-S. Lee, L.-W. Hsu, Y.-J. Chang, C.-N. Wang, H.-H. Peng, Y.-L. Chang, A.-S. Chao, et al.
Functional Network Analysis of the Transcriptomes of Mesenchymal Stem Cells Derived from Amniotic Fluid, Amniotic Membrane, Cord Blood, and Bone Marrow
Stem Cells, October 1, 2007; 25(10): 2511 - 2523.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
W. Shi, S. Bellusci, and D. Warburton
Lung Development and Adult Lung Diseases
Chest, August 1, 2007; 132(2): 651 - 656.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. D. Bland, L. Xu, R. Ertsey, M. Rabinovitch, K. H. Albertine, K. A. Wynn, V. H. Kumar, R. M. Ryan, D. D. Swartz, K. Csiszar, et al.
Dysregulation of pulmonary elastin synthesis and assembly in preterm lambs with chronic lung disease
Am J Physiol Lung Cell Mol Physiol, June 1, 2007; 292(6): L1370 - L1384.
[Abstract] [Full Text] [PDF]


Home page
Proc Am Thorac SocHome page
D. Warburton, J. Gauldie, S. Bellusci, and W. Shi
Lung Development and Susceptibility to Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, November 1, 2006; 3(8): 668 - 672.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
N. Mercier, M. Osborne-Pellegrin, K. El Hadri, A. Kakou, C. Labat, L. Loufrani, D. Henrion, P. Challande, S. Jalkanen, B. Feve, et al.
Carotid arterial stiffness, elastic fibre network and vasoreactivity in semicarbazide-sensitive amine-oxidase null mouse
Cardiovasc Res, November 1, 2006; 72(2): 349 - 357.
[Abstract] [Full Text] [PDF]


Home page
Proc Am Thorac SocHome page
A. Shifren and R. P. Mecham
The stumbling block in lung repair of emphysema: elastic fiber assembly.
Proceedings of the ATS, July 1, 2006; 3(5): 428 - 433.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the American Society for Investigative Pathology.