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(American Journal of Pathology. 2005;167:937-946.)
© 2005 American Society for Investigative Pathology

Analysis of Tumor Vessel Supply in Lewis Lung Carcinoma in Mice by Fluorescent Microsphere Distribution and Imaging with Micro- and Flat-Panel Computed Tomography

Rajkumar Savai*, Joachim C. Wolf{dagger}, Susanne Greschus{ddagger}, Bastian G. Eul*, Ralph T. Schermuly*, Jörg Hänze*, Robert Voswinckel*, Alexander C. Langheinrich{dagger}, Friedrich Grimminger*, Horst Traupe{ddagger}, Werner Seeger* and Frank Rose*

From the Departments of Internal Medicine/Pulmonary and Critical Care Medicine,* Radiology,{dagger} and Neuroradiology,{ddagger} Justus Liebig University, Giessen, Germany

In lung carcinomas the blood supply varies depending on tumor type and stage and can develop from pulmonary or bronchial circulation, or both. To examine this in vivo, primary bronchogenic Lewis lung carcinoma cells were intratracheally instilled in C57BL/6 mice. Within 7 days, histological examinations showed progressive tumor growth at the peripheral parenchymal region. The relative contribution of tumor blood supply via the pulmonary and systemic arteries was studied in detail using fluorescent microspheres (10 µm). When compared to healthy lung parenchyma (13:1), Lewis lung carcinoma tumor tissue (52:1) showed a fourfold increase in pulmonary to systemic microspheres, indicating that the pulmonary arteries are the predominant tumor-feeding vessels. After filling the vessels with a vascular cast, the microanatomy of vessels being derived from the pulmonary artery was visualized with micro computed tomography. Flat-panel volumetric computed tomography provided longitudinal visualization of tissue bridges between the growing tumor and the pulmonary vasculature. In this model of peripheral parenchymal malignancy, new imaging techniques allowed effective visualization of lung tumor growth and vascularization in living mice, demonstrating a pulmonary blood supply for lung tumors.




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