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(American Journal of Pathology. 2006;168:184-194.)
© 2006 American Society for Investigative Pathology

A Dynamic Relationship between Intracellular and Extracellular Pools of Aß

Salvatore Oddo, Antonella Caccamo, Ian F. Smith, Kim N. Green and Frank M. LaFerla

From the Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California

The accumulation of the amyloid-ß peptide (Aß) in the brain is considered to have a primary role in Alzheimer’s disease (AD). In addition to the extracellular accumulation of Aß in the parenchyma and cerebrovasculature, emerging evidence indicates that intraneuronal Aß also plays a pathophysiological role in AD. It is unclear, however, if the intracellular and extracellular pools of Aß are unrelated or connected. In these studies, we sought to establish a relationship between these two pools of Aß. We identified an inverse relationship between intracellular and extracellular Aß in the 3xTg-AD transgenic model of AD. Using an immunotherapy approach, we further found that extracellular Aß was cleared before intracellular Aß. After the antibody dissipated, however, the reappearance of extracellular plaques was preceded by the accumulation of intraneuronal Aß. Taken together, these results provide strong experimental evidence that intraneuronal Aß may serve as a source for some of the extracellular amyloid deposits.




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