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(American Journal of Pathology. 2006;169:1-11.)
© 2006 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2006.060121

Review

Role of the SurvivinGene in Pathophysiology

Fengzhi Li^* and Michael G. Brattain^*

From the Department of Pharmacology and Therapeutics,^* Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York; and the Cancer Institute and School of Life Science and Technology, Tongji University, Shanghai, China

Abstract

Although the roles of survivin in control of cancer cell division and apoptosis as well as targeting survivin for cancer therapeutics have been extensively explored and reviewed, the pathophysiological role of survivin in normal human cells/organs has not been deeply investigated or sufficiently reviewed. Studies in the latter area, however, appear to be important for the identification of different mechanisms of regulation and function of survivin in normal versus abnormal cells and tissues (including cancer), which might ultimately provide the basis for novel approaches for disease treatment with low toxicity. This Review is intended to summarize current observations in the literature related to the physiological and/or pathological roles for survivin in various normal human cells or organs. Our view of potential future research directions for survivin pertinent to potential therapeutic applications will also be discussed.

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