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(American Journal of Pathology. 2006;169:338-346.)
© 2006 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2006.060312


Biological Perspectives

Hematopoietic Stem Cells

The Paradigmatic Tissue-Specific Stem Cell

David Bryder, Derrick J. Rossi and Irving L. Weissman

From the Department of Pathology, Stanford University School of Medicine, Stanford, California

Abstract

The recent prospective isolation of a wide variety of somatically derived stem cells has affirmed the notion that homeostatic maintenance of most tissues and organs is mediated by tissue-specific stem and progenitor cells and fueled enthusiasm for the use of such cells in strategies aimed at repairing or replacing damaged, diseased, or genetically deficient tissues and organs. Hematopoietic stem cells (HSCs) are arguably the most well-characterized tissue-specific stem cell, with decades of basic research and clinical application providing not only a profound understanding of the principles of stem cell biology, but also of its potential pitfalls. It is our belief that emerging stem cell fields can benefit greatly from an understanding of the lessons learned from the study of HSCs. In this review we discuss some general concepts regarding stem cell biology learned from the study of HSCs with a highlight on recent work pertaining to emerging topics of interest for stem cell biology.





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