help button home button Am J Pathol ASIP 2008 Summer Academy, Molecular Methcanisms of Human Disease: Injury, Inflammation, and Tissue Repair
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bryder, D.
Right arrow Articles by Weissman, I. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bryder, D.
Right arrow Articles by Weissman, I. L.
(American Journal of Pathology. 2006;169:338-346.)
© 2006 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2006.060312


Biological Perspectives

Hematopoietic Stem Cells

The Paradigmatic Tissue-Specific Stem Cell

David Bryder, Derrick J. Rossi and Irving L. Weissman

From the Department of Pathology, Stanford University School of Medicine, Stanford, California

Abstract

The recent prospective isolation of a wide variety of somatically derived stem cells has affirmed the notion that homeostatic maintenance of most tissues and organs is mediated by tissue-specific stem and progenitor cells and fueled enthusiasm for the use of such cells in strategies aimed at repairing or replacing damaged, diseased, or genetically deficient tissues and organs. Hematopoietic stem cells (HSCs) are arguably the most well-characterized tissue-specific stem cell, with decades of basic research and clinical application providing not only a profound understanding of the principles of stem cell biology, but also of its potential pitfalls. It is our belief that emerging stem cell fields can benefit greatly from an understanding of the lessons learned from the study of HSCs. In this review we discuss some general concepts regarding stem cell biology learned from the study of HSCs with a highlight on recent work pertaining to emerging topics of interest for stem cell biology.





This article has been cited by other articles:


Home page
Stem CellsHome page
H. Huynh, S. Iizuka, M. Kaba, O. Kirak, J. Zheng, H. F. Lodish, and C. C. Zhang
Insulin-Like Growth Factor-Binding Protein 2 Secreted by a Tumorigenic Cell Line Supports Ex Vivo Expansion of Mouse Hematopoietic Stem Cells
Stem Cells, June 1, 2008; 26(6): 1628 - 1635.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
F. Grebien, M. A. Kerenyi, B. Kovacic, T. Kolbe, V. Becker, H. Dolznig, K. Pfeffer, U. Klingmuller, M. Muller, H. Beug, et al.
Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2
Blood, May 1, 2008; 111(9): 4511 - 4522.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
M. C. Yoder
BB9 ACEs the HSC compartment.
Blood, April 15, 2008; 111(8): 3912 - 3912.
[Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
D. Kent, M. Copley, C. Benz, B. Dykstra, M. Bowie, and C. Eaves
Regulation of Hematopoietic Stem Cells by the Steel Factor/KIT Signaling Pathway
Clin. Cancer Res., April 1, 2008; 14(7): 1926 - 1930.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
C. C. Zhang, M. Kaba, S. Iizuka, H. Huynh, and H. F. Lodish
Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation
Blood, April 1, 2008; 111(7): 3415 - 3423.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
R. P. Ertl, J. Chen, C. M. Astle, T. M. Duffy, and D. E. Harrison
Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated
Blood, February 1, 2008; 111(3): 1709 - 1716.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
N. Hosen, T. Yamane, M. Muijtjens, K. Pham, M. F. Clarke, and I. L. Weissman
Bmi-1-Green Fluorescent Protein-Knock-In Mice Reveal the Dynamic Regulation of Bmi-1 Expression in Normal and Leukemic Hematopoietic Cells
Stem Cells, July 1, 2007; 25(7): 1635 - 1644.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
A. Wilson, D.-L. Ardiet, C. Saner, N. Vilain, F. Beermann, M. Aguet, H. R. MacDonald, and O. Zilian
Normal Hemopoiesis and Lymphopoiesis in the Combined Absence of Numb and Numblike
J. Immunol., June 1, 2007; 178(11): 6746 - 6751.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
M. C. Yoder, L. E. Mead, D. Prater, T. R. Krier, K. N. Mroueh, F. Li, R. Krasich, C. J. Temm, J. T. Prchal, and D. A. Ingram
Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals
Blood, March 1, 2007; 109(5): 1801 - 1809.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the American Society for Investigative Pathology.