| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Biological Perspectives |
From the Department of Pathology, Stanford University School of Medicine, Stanford, California
Abstract
The recent prospective isolation of a wide variety of somatically derived stem cells has affirmed the notion that homeostatic maintenance of most tissues and organs is mediated by tissue-specific stem and progenitor cells and fueled enthusiasm for the use of such cells in strategies aimed at repairing or replacing damaged, diseased, or genetically deficient tissues and organs. Hematopoietic stem cells (HSCs) are arguably the most well-characterized tissue-specific stem cell, with decades of basic research and clinical application providing not only a profound understanding of the principles of stem cell biology, but also of its potential pitfalls. It is our belief that emerging stem cell fields can benefit greatly from an understanding of the lessons learned from the study of HSCs. In this review we discuss some general concepts regarding stem cell biology learned from the study of HSCs with a highlight on recent work pertaining to emerging topics of interest for stem cell biology.
This article has been cited by other articles:
 |
|
 |
|
  H. Chen, K. Matsumoto, and B. R. Stripp Bronchiolar Progenitor Cells Proceedings of the ATS, December 1, 2009; 6(7): 602 - 606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Bhattacharya, A. Czechowicz, A.G. L. Ooi, D. J. Rossi, D. Bryder, and I. L. Weissman Niche recycling through division-independent egress of hematopoietic stem cells J. Exp. Med., November 23, 2009; 206(12): 2837 - 2850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Kent, M. R. Copley, C. Benz, S. Wohrer, B. J. Dykstra, E. Ma, J. Cheyne, Y. Zhao, M. B. Bowie, Y. Zhao, et al. Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential Blood, June 18, 2009; 113(25): 6342 - 6350. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P Sieveking and M. K. Ng Cell therapies for therapeutic angiogenesis: back to the bench Vascular Medicine, May 1, 2009; 14(2): 153 - 166. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Ausoni and S. Sartore From fish to amphibians to mammals: in search of novel strategies to optimize cardiac regeneration J. Cell Biol., February 9, 2009; 184(3): 357 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.C. Spradling, T. Nystul, D. Lighthouse, L. Morris, D. Fox, R. Cox, T. Tootle, R. Frederick, and A. Skora Stem Cells and Their Niches: Integrated Units That Maintain Drosophila Tissues Cold Spring Harb Symp Quant Biol, November 6, 2008; (2008) sqb.2008.73.023v1. [Abstract] [PDF]
|
|
|
|
 |
|
 B. J. Chyla, I. Moreno-Miralles, M. A. Steapleton, M. A. Thompson, S. Bhaskara, M. Engel, and S. W. Hiebert Deletion of Mtg16, a Target of t(16;21), Alters Hematopoietic Progenitor Cell Proliferation and Lineage Allocation Mol. Cell. Biol., October 15, 2008; 28(20): 6234 - 6247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Hirschi, D. A. Ingram, and M. C. Yoder Assessing Identity, Phenotype, and Fate of Endothelial Progenitor Cells Arterioscler Thromb Vasc Biol, September 1, 2008; 28(9): 1584 - 1595. [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Guerrettaz, S. A. Johnson, and J. C. Cambier Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging PNAS, August 19, 2008; 105(33): 11898 - 11902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Stripp Hierarchical Organization of Lung Progenitor Cells: Is there An Adult Lung Tissue Stem Cell? Proceedings of the ATS, August 15, 2008; 5(6): 695 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Grebien, M. A. Kerenyi, B. Kovacic, T. Kolbe, V. Becker, H. Dolznig, K. Pfeffer, U. Klingmuller, M. Muller, H. Beug, et al. Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2 Blood, May 1, 2008; 111(9): 4511 - 4522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Yoder BB9 ACEs the HSC compartment Blood, April 15, 2008; 111(8): 3912 - 3912. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kent, M. Copley, C. Benz, B. Dykstra, M. Bowie, and C. Eaves Regulation of Hematopoietic Stem Cells by the Steel Factor/KIT Signaling Pathway Clin. Cancer Res., April 1, 2008; 14(7): 1926 - 1930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Zhang, M. Kaba, S. Iizuka, H. Huynh, and H. F. Lodish Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation Blood, April 1, 2008; 111(7): 3415 - 3423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Ertl, J. Chen, C. M. Astle, T. M. Duffy, and D. E. Harrison Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated Blood, February 1, 2008; 111(3): 1709 - 1716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Batten, N. A Rosenthal, and M. H Yacoub Immune response to stem cells and strategies to induce tolerance Phil Trans R Soc B, August 29, 2007; 362(1484): 1343 - 1356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Wilson, D.-L. Ardiet, C. Saner, N. Vilain, F. Beermann, M. Aguet, H. R. MacDonald, and O. Zilian Normal Hemopoiesis and Lymphopoiesis in the Combined Absence of Numb and Numblike J. Immunol., June 1, 2007; 178(11): 6746 - 6751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Yoder, L. E. Mead, D. Prater, T. R. Krier, K. N. Mroueh, F. Li, R. Krasich, C. J. Temm, J. T. Prchal, and D. A. Ingram Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals Blood, March 1, 2007; 109(5): 1801 - 1809. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
