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(American Journal of Pathology. 2006;169:815-822.)
© 2006 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2006.060037

Inflammatory Murine Skin Responses to UV-B Light Are Partially Dependent on Endothelin-1 and Mast Cells

Martin Metz*, Verena Lammel*, Bernhard F. Gibbs{dagger} and Marcus Maurer*{ddagger}

From the Department of Dermatology,* University of Mainz, Mainz, Germany; Department of Dermatology,{dagger} University of Lübeck, Lübeck, Germany; and Department of Dermatology and Allergy,{ddagger} Charité–Universitätsmedizin Berlin, Berlin, Germany

Endothelin (ET-1) has been shown to crucially contribute to UV-induced skin responses such as tanning. To test whether ET-1 is also involved in early cutaneous reactions to UV, we assessed ET-1 skin levels in UV-irradiated mice. In correlation with the levels of UV-induced skin inflammation, ET-1 concentrations increased substantially and continually. Moreover, blocking of ET-1 receptors (ETA) resulted in significantly decreased cutaneous inflammation following UV irradiation. When we assessed skin responses to ET-1 injections, we observed prominent mast cell degranulation and mast cell-dependent inflammation. Since mast cells also critically contributed to UV-induced inflammation, we determined the ET-1-dependent inflammatory response to UV in the absence and presence of these cells. Interestingly, ETA blockade did not decrease UV-induced inflammation in mast cell-deficient mice, unless these mice had been adoptively transferred with mast cells before irradiation. This indicates that skin inflammation due to UV irradiation is caused in part by ET-1 acting on skin mast cells.




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