help button home button Am J Pathol ASIP MEMBERSHIP
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eming, S. A.
Right arrow Articles by Roers, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eming, S. A.
Right arrow Articles by Roers, A.
(American Journal of Pathology. 2007;170:188-202.)
© 2007 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2007.060370

Accelerated Wound Closure in Mice Deficient for Interleukin-10

Sabine A. Eming*, Sabine Werner{dagger}, Philippe Bugnon{dagger}, Claudia Wickenhauser{ddagger}, Lisa Siewe*, Olaf Utermöhlen§, Jeffrey M. Davidson¶||, Thomas Krieg* and Axel Roers*

From the Department of Dermatology* and the Institutes for Pathology{ddagger} and Medical Microbiology, Immunology, and Hygiene,§ University of Cologne, Cologne, Germany; the Department of Biology,{dagger} Institute of Cell Biology, Eidgenössische Technische Hochschule Zurich, Honggerberg, Switzerland; the Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee; and the Research and Development Service Veterans Affairs Tennessee Valley Healthcare System,|| Nashville, Tennessee

The impact of the local inflammatory response on the process of wound healing has been debated for decades. In particular, the question whether infiltrating macrophages and granulocytes promote or impede tissue repair has received much attention. In the present study, we show that wound healing is accelerated in mice deficient for the anti-inflammatory cytokine interleukin (IL)-10. IL-10–/– mice closed excisional wounds significantly earlier compared with IL-10-competent control littermates. This effect was attributable to accelerated epithelialization as well as enhanced contraction of the wound tissue in the mutant animals. Increased {alpha}-smooth muscle actin expression in IL-10-deficient mice suggests that augmented myofibroblast differentiation is responsible for the enhanced contraction of wounds in mutant mice. The number of macrophages infiltrating the wound tissue was significantly increased in IL-10–/– mice compared with control littermates suggesting that this cell type mediates the accelerated tissue repair. These results show for the first time that IL-10 can impede wound repair.




This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
J. Wang, H. Jiao, T. L. Stewart, M. V. H. Lyons, H. A. Shankowsky, P. G. Scott, and E. E. Tredget
Accelerated wound healing in leukocyte-specific, protein 1-deficient mouse is associated with increased infiltration of leukocytes and fibrocytes
J. Leukoc. Biol., December 1, 2007; 82(6): 1554 - 1563.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Loke, I. Gallagher, M. G. Nair, X. Zang, F. Brombacher, M. Mohrs, J. P. Allison, and J. E. Allen
Alternative Activation Is an Innate Response to Injury That Requires CD4+ T Cells to be Sustained during Chronic Infection
J. Immunol., September 15, 2007; 179(6): 3926 - 3936.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
T. Yukami, M. Hasegawa, Y. Matsushita, T. Fujita, T. Matsushita, M. Horikawa, K. Komura, K. Yanaba, Y. Hamaguchi, T. Nagaoka, et al.
Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1
J. Leukoc. Biol., September 1, 2007; 82(3): 519 - 531.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American Society for Investigative Pathology.