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(American Journal of Pathology. 2007;170:457-468.)
© 2007 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2007.060554

The Contribution of B Cells to Renal Interstitial Inflammation

Florian Heller*, Maja T. Lindenmeyer*, Clemens D. Cohen*, Ulrike Brandt*, Dan Draganovici*, Michael Fischereder*, Matthias Kretzler*, Hans-Joachim Anders*, Thomas Sitter*, Isabella Mosberger{dagger}, Dontscho Kerjaschki{dagger}, Heinz Regele{dagger}, Detlef Schlöndorff* and Stephan Segerer*

From the Medizinische Poliklinik-Innenstadt,* University of Munich, Munich, Germany; and the Clinical Institute of Pathology,{dagger} University of Vienna, Vienna, Austria

Local B-cell infiltrates play a role in tissue fibrosis, neolymphangiogenesis, and renal allograft survival. We sought to characterize the B-cell infiltrates, factors involved in B-cell recruitment, and lymphangiogenesis in renal interstitial injury (ie, acute and chronic interstitial nephritis and chronic IgA nephropathy). CD20-positive B cells formed a prominent part of the interstitial infiltrating cells. Together with CD3-positive T cells, the CD20-positive B cells formed larger nodular structures. CD10-positive pre-B cells were rare, and the majority were mature CD27-positive B cells. Proliferating B cells were detected within nodular infiltrates. The level of mRNA expression of the chemokine CXCL13 was increased and correlated with CD20 mRNA in the tubulointerstitial space. CXCL13 protein was predominantly found at sites of nodular infiltrates, in association with CXCR5-positive B cells. Furthermore, sites of chronic interstitial inflammation were associated with a high number of lymphatic vessels. B-cell infiltrates form a prominent part of the interstitial infiltrates both in primary interstitial lesions and in IgA nephropathy. CXCR5-positive B cells might be recruited via the chemokine CXCL13 and seem to contribute to the formation of intrarenal lymphoid follicle-like structures. These might represent an intrarenal immune system.




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