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*Severe Acute Respiratory Syndrome
(American Journal of Pathology. 2007;170:538-545.)
© 2007 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2007.060469

Molecular Pathology in the Lungs of Severe Acute Respiratory Syndrome Patients

Juxiang Ye*, Bo Zhang*, Jian Xu{dagger}, Qing Chang*, Michael A. McNutt*, Christine Korteweg*, Encong Gong* and Jiang Gu*{ddagger}

From the Department of Pathology,* School of Basic Medical Science, Peking University Health Science Center, Beijing, China; the Department of Histology and Embryology,{dagger} Peking University Health Science Center, Beijing, China; and the Department of Pathology,{ddagger} State University of New York–Health Science Center at Brooklyn, Brooklyn, New York

Severe acute respiratory syndrome (SARS) is a novel infectious disease with disastrous clinical consequences, in which the lungs are the major target organs. Previous studies have described the general pathology in the lungs of SARS patients and have identified some of the cell types infected by SARS coronavirus (SARS-CoV). However, at the time of this writing, there were no comprehensive reports of the cellular distribution of the virus in lung tissue. In this study, we have performed double labeling combining in situ hybridization with immunohistochemistry and alternating each of these techniques separately in consecutive sections to evaluate the viral distribution on various cell types in the lungs of seven patients affected with SARS. We found that SARS-CoV was present in bronchial epithelium, type I and II pneumocytes, T lymphocytes, and macrophages/monocytes. For pneumocytes, T lymphocytes, and macrophages, the infection rates were calculated. In addition, our present study is the first to demonstrate infection of endothelial cells and fibroblasts in SARS.




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