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(American Journal of Pathology. 2007;170:990-1002.)
© 2007 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2007.060507

Interleukin-1 Receptor Type 1 Is Essential for Control of Cerebral but Not Systemic Listeriosis

Martina Deckert*, Simona Virna{dagger}, Monika Sakowicz-Burkiewicz{ddagger}, Sonja Lütjen{dagger}, Sabine Soltek{dagger}, Horst Bluethmann§ and Dirk Schlüter{dagger}{ddagger}

From the Abteilung für Neuropathologie,* Universität zu Köln, Köln, Germany; the Institut für Medizinische Mikrobiologie und Hygiene,{dagger} Fakultät für klinische Medizin Mannheim der Universität Heidelberg, Mannheim, Germany; the Institut für Medizinische Mikrobiologie,{ddagger} Otto-von-Guericke Universität Magdeburg, Magdeburg, Germany; and the Roche Center for Medical Genomics,§ F. Hoffmann-La Roche, Basel, Switzerland

Listeria monocytogenes may infect the central nervous system and several peripheral organs. To explore the function of IL-1 receptor type 1 (IL-1R1) in cerebral versus systemic listeriosis, IL-1R1–/– and wild-type mice were infected either intracerebrally or intraperitoneally with L. monocytogenes. After intracerebral infection with various numbers of attenuated Listeria, IL-1R1–/– mice succumbed due to an insufficient control of intracerebral Listeria, whereas all wild-type mice survived, efficiently restricting growth of Listeria. IL-1R1–/– mice recruited increased numbers of leukocytes, especially granulocytes, to the brain compared with wild-type mice. In contrast, both IL-1R1–/– and wild-type mice survived a primary and secondary intraperitoneal infection with Listeria without differences in the hepatic bacterial load. In addition, both strains developed similar frequencies of Listeria-specific CD4 and CD8 T cells after primary and secondary intraperitoneal infection. However, an intraperitoneal immunization before intracerebral challenge infection neither protected IL-1R1–/– mice from death nor reduced the intracerebral bacterial load, although numbers of intracerebral Listeria-specific CD4 and CD8 T cells and levels of inducible nitric oxide synthase, tumor necrosis factor, and interferon-{gamma} mRNA were identical in IL-1R1–/– and wild-type mice. Collectively, these findings illustrate a crucial role of IL-1R1 in cerebral but not systemic listeriosis.




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Copyright © 2007 by the American Society for Investigative Pathology.