help button home button Am J Pathol Epitomics, Inc.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gratzinger, D.
Right arrow Articles by Natkunam, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gratzinger, D.
Right arrow Articles by Natkunam, Y.
(American Journal of Pathology. 2007;170:1362-1369.)
© 2007 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2007.060901

Microvessel Density and Expression of Vascular Endothelial Growth Factor and Its Receptors in Diffuse Large B-Cell Lymphoma Subtypes

Dita Gratzinger*, Shuchun Zhao*, Robert J. Marinelli{dagger}, Amy V. Kapp{ddagger}, Robert J. Tibshirani{ddagger}, Anne S. Hammer§, Stephen Hamilton-Dutoit§ and Yasodha Natkunam*

From the Departments of Pathology,* Biochemistry,{dagger} and Health Research and Policy,{ddagger} Stanford University, Stanford, California; and Institute of Pathology,§ Aarhus University Hospital, Aarhus, Denmark

Angiogenesis is known to play a major role in neoplasia, including hematolymphoid neoplasia. We assessed the relationships among angiogenesis and expression of vascular endothelial growth factor and its receptors in the context of clinically and biologically relevant subtypes of diffuse large B-cell lymphoma using immunohistochemical evaluation of tissue microarrays. We found that diffuse large B-cell lymphoma specimens showing higher local vascular endothelial growth factor expression showed correspondingly higher microvessel density, implying that lymphoma cells induce local tumor angiogenesis. In addition, local vascular endothelial growth factor expression was higher in those specimens showing higher expression of the receptors of the growth factor, suggesting an autocrine growth-promoting feedback loop. The germinal center-like and nongerminal center-like subtypes of diffuse large B-cell lymphoma were biologically and prognostically distinct. Interestingly, only in the more clinically aggressive nongerminal center-like subtype were microvessel densities significantly higher in specimens showing higher vascular endothelial growth factor expression; the same was true for the finding of higher vascular endothelial growth factor receptor-1 expression in conjunction with higher vascular endothelial growth factor expression. These differences may have important implications for the responsiveness of the two diffuse large B-cell lymphoma subtypes to anti-vascular endothelial growth factor and anti-angiogenic therapies.




This article has been cited by other articles:


Home page
 Ann OncolHome page
J. Ruan, K. Hajjar, S. Rafii, and J. P. Leonard
Angiogenesis and antiangiogenic therapy in non-Hodgkin's lymphoma
Ann. Onc., March 1, 2009; 20(3): 413 - 424.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
R. J. Marinelli, K. Montgomery, C. L. Liu, N. H. Shah, W. Prapong, M. Nitzberg, Z. K. Zachariah, G. J. Sherlock, Y. Natkunam, R. B. West, et al.
The Stanford Tissue Microarray Database
Nucleic Acids Res., January 11, 2008; 36(suppl_1): D871 - D877.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American Society for Investigative Pathology.