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(American Journal of Pathology. 2007;170:1535-1545.)
© 2007 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2007.060478

Loss of Fibulin-2 Expression Is Associated with Breast Cancer Progression

Chun-Hui Yi*{dagger}, David J. Smith{dagger}, William W. West{dagger} and Michael A. Hollingsworth*{dagger}{ddagger}

From the Eppley Institute for Research in Cancer and Allied Diseases,* and the Departments of Pathology and Microbiology{dagger} and Biochemistry and Molecular Biology,{ddagger} University of Nebraska Medical Center, Omaha, Nebraska

Fibulin-2, an extracellular matrix protein expressed by normal epithelia, was found to be down-regulated in several breast cancer cell lines. Fibulin-2 protein expression was also decreased in breast cancer tissue samples as evaluated by immunohistochemistry. Reintroduction of Fibulin-2 into breast cancer cell lines that do not express Fibulin-2 reduced cancer cell motility and invasion in vitro but had no effect on cell growth and adhesion properties. Together with evidence that Fibulin-2 contributes to wound healing and inhibits smooth muscle cell migration, our findings suggest that loss of Fibulin-2 expression may facilitate migration and invasion in breast cancer.




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