help button home button Am J Pathol R & D Systems
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Material
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yi, C.-H.
Right arrow Articles by Hollingsworth, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yi, C.-H.
Right arrow Articles by Hollingsworth, M. A.
(American Journal of Pathology. 2007;170:1535-1545.)
© 2007 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2007.060478

Loss of Fibulin-2 Expression Is Associated with Breast Cancer Progression

Chun-Hui Yi*{dagger}, David J. Smith{dagger}, William W. West{dagger} and Michael A. Hollingsworth*{dagger}{ddagger}

From the Eppley Institute for Research in Cancer and Allied Diseases,* and the Departments of Pathology and Microbiology{dagger} and Biochemistry and Molecular Biology,{ddagger} University of Nebraska Medical Center, Omaha, Nebraska

Fibulin-2, an extracellular matrix protein expressed by normal epithelia, was found to be down-regulated in several breast cancer cell lines. Fibulin-2 protein expression was also decreased in breast cancer tissue samples as evaluated by immunohistochemistry. Reintroduction of Fibulin-2 into breast cancer cell lines that do not express Fibulin-2 reduced cancer cell motility and invasion in vitro but had no effect on cell growth and adhesion properties. Together with evidence that Fibulin-2 contributes to wound healing and inhibits smooth muscle cell migration, our findings suggest that loss of Fibulin-2 expression may facilitate migration and invasion in breast cancer.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American Society for Investigative Pathology.