| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Published online before print April 19, 2007
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Biological Perspectives |
From the Laboratory of Cell Biophysics,* École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; the Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; the Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan; the Department of Clinical Pathophysiology, University of Florence, Florence, Italy; and the Department of Immunology and Pathology,¶ C.M.U., University of Geneva, Geneva, Switzerland
Abstract
The crucial role played by the myofibroblast in wound healing and pathological organ remodeling is well established; the general mechanisms of extracellular matrix synthesis and of tension production by this cell have been amply clarified. This review discusses the pattern of myofibroblast accumulation and fibrosis evolution during lung and liver fibrosis as well as during atheromatous plaque formation. Special attention is paid to the specific features characterizing each of these processes, including the spectrum of different myofibroblast precursors and the distinct pathways involved in the formation of differentiated myofibroblasts in each lesion. Thus, whereas in lung fibrosis it seems that most myofibroblasts derive from resident fibroblasts, hepatic stellate cells are the main contributor for liver fibrosis and media smooth muscle cells are the main contributor for the atheromatous plaque. A better knowledge of the molecular mechanisms conducing to the appearance of differentiated myofibroblasts in each pathological situation will be useful for the understanding of fibrosis development in different organs and for the planning of strategies aiming at their prevention and therapy.
This article has been cited by other articles:
 |
|
 |
|
  C. N. Kohler The Actin-binding Protein Caldesmon Is in Spleen and Lymph Nodes Predominately Expressed by Smooth-muscle Cells, Reticular Cells, and Follicular Dendritic Cells J. Histochem. Cytochem., February 1, 2010; 58(2): 183 - 193. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Dalla Costa, C. F.M.Z. Clemente, H. F. Carvalho, J. B. Carvalheira, W. Nadruz Jr, and K. G. Franchini FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complex Cardiovasc Res, January 22, 2010; (2010): cvp416v2 - cvp416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Westwood, R. C. Scott, R. L. Somers, M. Coulson, and R. A. Maciewicz Characterization of Fibrodysplasia in the Dog Following Inhibition of Metalloproteinases Toxicol Pathol, December 1, 2009; 37(7): 860 - 872. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Schuliga, I. See, S. C. Ong, L. Soon, B. Camoretti-Mercado, T. Harris, and A. G. Stewart Fibrillar Collagen Clamps Lung Mesenchymal Cells in a Nonproliferative and Noncontractile Phenotype Am. J. Respir. Cell Mol. Biol., December 1, 2009; 41(6): 731 - 741. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Watanabe, A. Masamune, K. Kikuta, M. Hirota, K. Kume, K. Satoh, and T. Shimosegawa Bone marrow contributes to the population of pancreatic stellate cells in mice Am J Physiol Gastrointest Liver Physiol, December 1, 2009; 297(6): G1138 - G1146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Frid, M. Li, M. Gnanasekharan, D. L. Burke, M. Fragoso, D. Strassheim, J. L. Sylman, and K. R. Stenmark Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall Am J Physiol Lung Cell Mol Physiol, December 1, 2009; 297(6): L1059 - L1072. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wu, C. Mei, H. Vlassara, G. E. Striker, and F. Zheng Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells Am J Physiol Renal Physiol, December 1, 2009; 297(6): F1622 - F1631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kulasekaran, C. A. Scavone, D. S. Rogers, D. A. Arenberg, V. J. Thannickal, and J. C. Horowitz Endothelin-1 and Transforming Growth Factor-{beta}1 Independently Induce Fibroblast Resistance to Apoptosis via AKT Activation Am. J. Respir. Cell Mol. Biol., October 1, 2009; 41(4): 484 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sandbo, S. Kregel, S. Taurin, S. Bhorade, and N. O. Dulin Critical Role of Serum Response Factor in Pulmonary Myofibroblast Differentiation Induced by TGF-{beta} Am. J. Respir. Cell Mol. Biol., September 1, 2009; 41(3): 332 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Peterfi, A. Donko, A. Orient, A. Sum, A. Prokai, B. Molnar, Z. Vereb, E. Rajnavolgyi, K. J. Kovacs, V. Muller, et al. Peroxidasin Is Secreted and Incorporated into the Extracellular Matrix of Myofibroblasts and Fibrotic Kidney Am. J. Pathol., August 1, 2009; 175(2): 725 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D. Boudoulas and A. K. Hatzopoulos Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease Dis. Model. Mech., July 1, 2009; 2(7-8): 344 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zheng, Z. Zhou, L. Lin, S. Alber, S. Watkins, N. Kaminski, A. M. K. Choi, and D. Morse Carbon Monoxide Modulates {alpha}-Smooth Muscle Actin and Small Proline Rich-1a Expression in Fibrosis Am. J. Respir. Cell Mol. Biol., July 1, 2009; 41(1): 85 - 92. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. W. Morrell, S. Adnot, S. L. Archer, J. Dupuis, P. Lloyd Jones, M. R. MacLean, I. F. McMurtry, K. R. Stenmark, P. A. Thistlethwaite, N. Weissmann, et al. Cellular and molecular basis of pulmonary arterial hypertension. J. Am. Coll. Cardiol., June 30, 2009; 54(1 Suppl): S20 - S31. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Abraham, T. Krieg, J. Distler, and O. Distler Overview of pathogenesis of systemic sclerosis Rheumatology, June 1, 2009; 48(suppl_3): iii3 - iii7. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Peduto, S. Dulauroy, M. Lochner, G. F. Spath, M. A. Morales, A. Cumano, and G. Eberl Inflammation Recapitulates the Ontogeny of Lymphoid Stromal Cells J. Immunol., May 1, 2009; 182(9): 5789 - 5799. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Berni, M. Savi, L. Bocchi, F. Delucchi, E. Musso, C. Chaponnier, G. Gabbiani, S. Clement, and D. Stilli Modulation of actin isoform expression before the transition from experimental compensated pressure-overload cardiac hypertrophy to decompensation Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1625 - H1632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Gellings Lowe, J. S. Swaney, K. M. Moreno, and R. A. Sabbadini Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-{beta}-stimulated collagen production by cardiac fibroblasts Cardiovasc Res, May 1, 2009; 82(2): 303 - 312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Suzuki, D. Sawaki, K. Aizawa, Y. Munemasa, T. Matsumura, J. Ishida, and R. Nagai Kruppel-like Factor 5 Shows Proliferation-specific Roles in Vascular Remodeling, Direct Stimulation of Cell Growth, and Inhibition of Apoptosis J. Biol. Chem., April 3, 2009; 284(14): 9549 - 9557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Schissel, S. E. Dunsmore, X. Liu, R. W. Shine, M. A. Perrella, and M. D. Layne Aortic Carboxypeptidase-Like Protein Is Expressed in Fibrotic Human Lung and its Absence Protects against Bleomycin-Induced Lung Fibrosis Am. J. Pathol., March 1, 2009; 174(3): 818 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ausoni and S. Sartore From fish to amphibians to mammals: in search of novel strategies to optimize cardiac regeneration J. Cell Biol., February 9, 2009; 184(3): 357 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. I. Jobling, A. Gentle, R. Metlapally, B. J. McGowan, and N. A. McBrien Regulation of Scleral Cell Contraction by Transforming Growth Factor-{beta} and Stress: COMPETING ROLES IN MYOPIC EYE GROWTH J. Biol. Chem., January 23, 2009; 284(4): 2072 - 2079. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B R Klass, A O Grobbelaar, and K J Rolfe Transforming growth factor {beta}1 signalling, wound healing and repair: a multifunctional cytokine with clinical implications for wound repair, a delicate balance Postgrad. Med. J., January 1, 2009; 85(999): 9 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Chambers Abnormal wound healing responses in pulmonary fibrosis: focus on coagulation signalling Eur. Respir. Rev., December 1, 2008; 17(109): 130 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Vaahtomeri, E. Ventela, K. Laajanen, P. Katajisto, P.-J. Wipff, B. Hinz, T. Vallenius, M. Tiainen, and T. P. Makela Lkb1 is required for TGF{beta}-mediated myofibroblast differentiation J. Cell Sci., November 1, 2008; 121(21): 3531 - 3540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Plantier, C Rochette-Egly, D Goven, A Boutten, M Bonay, G Leseche, M Fournier, B Crestani, and J Boczkowski Dysregulation of elastin expression by fibroblasts in pulmonary emphysema: role of cellular retinoic acid binding protein 2 Thorax, November 1, 2008; 63(11): 1012 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Schoen Evolving Concepts of Cardiac Valve Dynamics: The Continuum of Development, Functional Structure, Pathobiology, and Tissue Engineering Circulation, October 28, 2008; 118(18): 1864 - 1880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Ding, C. L. Gladson, H. Wu, H. Hayasaka, and M. A. Olman Focal Adhesion Kinase (FAK)-related Non-kinase Inhibits Myofibroblast Differentiation through Differential MAPK Activation in a FAK-dependent Manner J. Biol. Chem., October 3, 2008; 283(40): 26839 - 26849. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Herzog, A. R. Brody, T. V. Colby, R. Mason, and M. C. Williams Knowns and Unknowns of the Alveolus Proceedings of the ATS, September 15, 2008; 5(7): 778 - 782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Stevens, S. Phan, M. G. Frid, D. Alvarez, E. Herzog, and K. R. Stenmark Lung Vascular Cell Heterogeneity: Endothelium, Smooth Muscle, and Fibroblasts Proceedings of the ATS, September 15, 2008; 5(7): 783 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Hinson, M. D. Medlin, J. M. Taylor, and C. P. Mack Regulation of myocardin factor protein stability by the LIM-only protein FHL2 Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1067 - H1075. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Strutz The great escape--myofibroblasts in fibrosis and the immune system Nephrol. Dial. Transplant., August 1, 2008; 23(8): 2477 - 2479. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Eferl, P. Hasselblatt, M. Rath, H. Popper, R. Zenz, V. Komnenovic, M.-H. Idarraga, L. Kenner, and E. F. Wagner Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1 PNAS, July 29, 2008; 105(30): 10525 - 10530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sasaki, T. Nakamura, R. B. Rebhun, H. Cheng, K. S. Hale, R. Z. Tsan, I. J. Fidler, and R. R. Langley Modification of the Primary Tumor Microenvironment by Transforming Growth Factor {alpha}-Epidermal Growth Factor Receptor Signaling Promotes Metastasis in an Orthotopic Colon Cancer Model Am. J. Pathol., July 1, 2008; 173(1): 205 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Gonias Urokinase: the identity crisis continues Blood, July 1, 2008; 112(1): 8 - 8. [Full Text] [PDF]
|
|
|
|
|
|
D. V. Pechkovsky, A. K. Scaffidi, T. L. Hackett, J. Ballard, F. Shaheen, P. J. Thompson, V. J. Thannickal, and D. A. Knight Transforming Growth Factor {beta}1 Induces {alpha}v{beta}3 Integrin Expression in Human Lung Fibroblasts via a {beta}3 Integrin-, c-Src-, and p38 MAPK-dependent Pathway J. Biol. Chem., May 9, 2008; 283(19): 12898 - 12908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mishra, B. L. Cool, K. R. Laderoute, M. Foretz, B. Viollet, and M. S. Simonson AMP-activated Protein Kinase Inhibits Transforming Growth Factor-{beta}-induced Smad3-dependent Transcription and Myofibroblast Transdifferentiation J. Biol. Chem., April 18, 2008; 283(16): 10461 - 10469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Phan Biology of Fibroblasts and Myofibroblasts Proceedings of the ATS, April 15, 2008; 5(3): 334 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kisseleva and D. A. Brenner Fibrogenesis of Parenchymal Organs Proceedings of the ATS, April 15, 2008; 5(3): 338 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. F. Voelkel Conference Summary Proceedings of the ATS, April 15, 2008; 5(3): 354 - 357. [Full Text] [PDF]
|
|
|
|
|
|
T. Kielian, M. Md. Syed, S. Liu, N. K. Phulwani, N. Phillips, G. Wagoner, P. D. Drew, and N. Esen The Synthetic Peroxisome Proliferator-Activated Receptor-{gamma} Agonist Ciglitazone Attenuates Neuroinflammation and Accelerates Encapsulation in Bacterial Brain Abscesses J. Immunol., April 1, 2008; 180(7): 5004 - 5016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Zahradka Novel Role for Osteopontin in Cardiac Fibrosis Circ. Res., February 15, 2008; 102(3): 270 - 272. [Full Text] [PDF]
|
|
|
|
 |
|
 H. L. Ashurst, A. Varro, and R. Dimaline Regulation of mammalian gastrin/CCK receptor (CCK2R) expression in vitro and in vivo Exp Physiol, February 1, 2008; 93(2): 223 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Friedman Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver Physiol Rev, January 1, 2008; 88(1): 125 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Horowitz, D. S. Rogers, R. H. Simon, T. H. Sisson, and V. J. Thannickal Plasminogen Activation Induced Pericellular Fibronectin Proteolysis Promotes Fibroblast Apoptosis Am. J. Respir. Cell Mol. Biol., January 1, 2008; 38(1): 78 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-J. Wipff, D. B. Rifkin, J.-J. Meister, and B. Hinz Myofibroblast contraction activates latent TGF- 1 from the extracellular matrix J. Cell Biol., December 17, 2007; 179(6): 1311 - 1323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Hagood and M. A. Olman Muscle Fatigue: MK2 Signaling and Myofibroblast Differentiation Am. J. Respir. Cell Mol. Biol., November 1, 2007; 37(5): 503 - 506. [Full Text] [PDF]
|
|
|
|
|
|
S. Pellegrin and H. Mellor Actin stress fibres J. Cell Sci., October 15, 2007; 120(20): 3491 - 3499. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
