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Originally published online as doi:10.2353/ajpath.2007.061016 on April 13, 2007

Published online before print April 13, 2007
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(American Journal of Pathology. 2007;170:2001-2008.)
© 2007 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2007.061016

p150/95 (CD11c/CD18) Expression Is Required for the Development of Experimental Autoimmune Encephalomyelitis

Daniel C. Bullard*, Xianzhen Hu{dagger}, Jillian E. Adams{dagger}, Trenton R. Schoeb* and Scott R. Barnum{dagger}{ddagger}

From the Departments of Genetics,* Microbiology,{dagger} and Neurology,{ddagger} University of Alabama at Birmingham, Birmingham, Alabama

p150/95 (CD11c/CD18, CR4) is a member of the ß2-integrin family of adhesion molecules and is considered an important phagocytic receptor. The role of p150/95 in the development of central nervous system demyelinating diseases, including multiple sclerosis, remains unexplored. To determine p150/95-mediated mechanisms in experimental autoimmune encephalomyelitis (EAE), we performed EAE using CD11c-deficient (CD11c–/–) mice. EAE in CD11c–/– mice was significantly attenuated and characterized by markedly reduced spinal cord T-cell infiltration and interferon-{gamma} production by these cells. Adoptive transfer of antigen-restimulated T cells from wild-type to CD11c–/– mice produced significantly attenuated EAE, whereas transfer of CD11c–/– antigen-restimulated T cells to control mice induced a very mild, monophasic EAE. T cells from MOG35–55 peptide-primed CD11c–/– mice displayed an unusual cytokine phenotype with elevated levels of interleukin (IL)-2, IL-4, and IL-12 but reduced levels of interferon-{gamma}, tumor necrosis factor-{alpha}, IL-10, IL-17, and transforming growth factor-ß compared with control mice. Overall, CD11c–/– T cells from primed mice proliferated comparably to that of control T cells on MOG35-55 restimulation. Our results indicate that expression of p150/95 is critical on both T cells as well as other leukocytes for the development of demyelinating disease and may represent a novel therapeutic target for multiple sclerosis.




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S. S. Smith and S. R. Barnum
Differential expression of 2-integrins and cytokine production between {gamma}{delta} and {alpha} T cells in experimental autoimmune encephalomyelitis
J. Leukoc. Biol., January 1, 2008; 83(1): 71 - 79.
[Abstract] [Full Text] [PDF]


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