Published online before print May 18, 2007

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(American Journal of Pathology. 2007;171:2-8.)
© 2007 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2007.070135

Biological Perspectives

Immunological Consequences of Apoptotic Cell Phagocytosis

Lars-Peter Erwig^* and Peter M. Henson

From the Department of Medicine and Therapeutics,^* Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom; and the Program in Cell Biology, Department of Paediatrics, National Jewish Medical and Research Center, Denver, Colorado

Abstract

Cells undergo apoptosis in development, tissue homeostasis, and disease and are subsequently cleared by professional and nonprofessional phagocytes. There is now overwhelming evidence that phagocyte function is profoundly altered following apoptotic cell uptake, with consequences for the ensuing innate and adaptive immune response. Pathogens and tumors exploit the changes in macrophage function following apoptotic cell uptake. Here, we will outline the consequences of apoptotic cell phagocytosis and illustrate how apoptotic cells could be used to manipulate the immune response for therapeutic gain.

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