help button home button Am J Pathol Epitomics, Inc.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Originally published online as doi:10.2353/ajpath.2008.080556 on November 6, 2008

Published online before print November 6, 2008
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
ajpath.2008.080556v1
173/6/1882    most recent
Right arrow Purchase Article
Right arrow View Shopping Cart
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tracz, M. J.
Right arrow Articles by Nath, K. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tracz, M. J.
Right arrow Articles by Nath, K. A.
(American Journal of Pathology. 2008;173:1882-1890.)
© 2008 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2008.080556

Induction of Heme Oxygenase-1 is a Beneficial Response in a Murine Model of Venous Thrombosis

Michal J. Tracz*, Julio P. Juncos*, Joseph P. Grande*{dagger}, Anthony J. Croatt*, Allan W. Ackerman*, Zvonimir S. Katusic{ddagger} and Karl A. Nath*

From the Division of Nephrology and Hypertension,* Department of Pathology,{dagger} Departments of Anesthesiology and Molecular Pharmacology and Experimental Therapeutics,{ddagger} Mayo Clinic, Rochester, Minnesota

The induction of heme oxygenase-1 (HO-1) may protect against tissue injury. The present study examines the induction of HO-1 in a murine model of venous thrombosis and explores the downstream consequences of this induction. In a model of stasis-induced thrombosis created by ligation of the inferior vena cava, HO-1 expression is markedly induced. Such expression occurs primarily in smooth muscle cells in the venous wall and in leukocytes infiltrating the venous wall and clot. To determine the significance of HO-1 induction in venous thrombosis, this model was imposed in HO-1+/+ and HO-1–/– mice. The initial clot size did not differ in either group by day 2, but was significantly larger in HO-1–/– mice by day 10, where an exaggerated inflammatory response in the venous wall was also observed. Following ligation of the inferior vena cava, HO-1–/– mice exhibited increased nuclear factor {kappa}B activation and markedly increased up-regulation of tissue factor, selectins, inflammatory cytokines, and matrix metalloproteinase-9, the latter incriminated in both clot lysis and vascular injury. We conclude that HO-1 deficiency impairs thrombus resolution and exaggerates the inflammatory response to thrombus formation. These findings offer insight into recent observations that polymorphisms in the HO-1 gene may increase the risk for recurrent venous thrombosis and dysfunction of hemodialysis arteriovenous fistulas, the latter caused, in part, by thrombosis.




This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
B. Chen, L. Guo, C. Fan, S. Bolisetty, R. Joseph, M. M. Wright, A. Agarwal, and J. F. George
Carbon Monoxide Rescues Heme Oxygenase-1-Deficient Mice from Arterial Thrombosis in Allogeneic Aortic Transplantation
Am. J. Pathol., July 1, 2009; 175(1): 422 - 429.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the American Society for Investigative Pathology.