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Originally published online as doi:10.2353/ajpath.2009.080794 on March 5, 2009

Published online before print March 5, 2009
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(American Journal of Pathology. 2009;174:1131-1138.)
© 2009 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2009.080794

Keynote Lecture

MiRNAs and Cancer

Rosa Visone and Carlo M. Croce

From the Department of Molecular Virology, Immunology, and Medical Genetics, and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio

Abstract

Cancer is the result of a complex multistep process that involves the accumulation of sequential alterations of several genes, including those encoding microRNAs (miRNAs). miRNAs are a class of 17- to 27-nucleotide single-stranded RNA molecules that regulate gene expression posttranscriptionally. A large body of evidence implicates aberrant miRNA expression patterns in most, if not all, human malignancies. This article reviews our current knowledge about miRNAs, focusing on their involvement in cancer and their potential as diagnostic, prognostic, and therapeutic tools.




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