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Originally published online as doi:10.2353/ajpath.2009.081143 on April 30, 2009

Published online before print April 30, 2009
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(American Journal of Pathology. 2009;174:1985-1992.)
© 2009 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2009.081143

Mini-Review

Very Small Embryonic/Epiblast-Like Stem Cells

A Missing Link To Support the Germ Line Hypothesis of Cancer Development?

Mariusz Z. Ratajczak, Dong-Myung Shin and Magda Kucia

From the Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky

Abstract

The morphology of several tumors mimics developmentally early tissues, and tumors often express early developmental markers characteristic of the germ line lineage. The presence of these markers in neoplastic cells could reflect the dedifferentiation of somatic cells in which cancer develops or cancer origination in primitive stem cells closely related to the epiblast/germ line. The identification of primitive germ line-derived very small embryonic/epiblast-like stem cells, which are deposited early in embryogenesis in developing organs and persist in several organs into adulthood, raised the possibility that cancer may originate in these cells. In this review, we hypothesize that very small embryonic/epiblast-like stem cells could be a missing link that support the more than 100-year-old concepts of the embryonic rest or germ line origin hypotheses of cancer development; however, further experimental evidence is needed to support this hypothesis.






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Copyright © 2009 by the American Society for Investigative Pathology.