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Originally published online as doi:10.2353/ajpath.2009.090689 on October 8, 2009

Published online before print October 8, 2009
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(American Journal of Pathology. 2009;175:1799-1801.)
© 2009 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2009.090689

Commentary

Control of Lung Epithelial Growth by a Nicotinic Acetylcholine Receptor

The Other Side of the Coin

Jesse Roman*{dagger} and Michael Koval*{ddagger}

From the Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine* and the Department of Cell Biology,{ddagger} Emory University School of Medicine, Atlanta; and the Veterans Affairs Medical Center,{dagger} Atlanta, Georgia

Abstract

This Commentary provides a perspective on an article in the current issue of the American Journal of Pathology by Maouche et al, which demonstrates that {alpha}7 nicotinic acetylcholine receptors play a key role in regulating airway regeneration by limiting basal epithelial cell proliferation.


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{alpha}7 Nicotinic Acetylcholine Receptor Regulates Airway Epithelium Differentiation by Controlling Basal Cell Proliferation
Kamel Maouche, Myriam Polette, Thomas Jolly, Kahina Medjber, Isabelle Cloëz-Tayarani, Jean-Pierre Changeux, Henriette Burlet, Christine Terryn, Christelle Coraux, Jean-Marie Zahm, Philippe Birembaut, and Jean-Marie Tournier
Am. J. Pathol. 2009 175: 1868-1882. [Abstract] [Full Text] [PDF]





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