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American Journal of Pathology, Vol 78, 497-504, Copyright © 1975 by American Society for Investigative Pathology

REGULAR ARTICLES

Lipid accumulation in smooth muscle cell lysosomes im primate atherosclerosis

S Goldfischer, B Schiller and H Wolinsky

Cytochemical and ultrastructural examination of the developing atherosclerotic lesion in hypercholesterolemic rhesus monkeys reveals that lipid is sequestered within lysosomes of aortic smooth muscle cells. A common pathway in the development of sclerotic arterial disease appears to be overloading of vascular smooth muscle cell lysosomes with a variety of metabolites. This may occur as a consequence of an excess of substrate or because of a congenital deficiency of a lysosomal hydrolase.


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Copyright © 1975 by the American Society for Investigative Pathology.