help button home button Am J Pathol R & D Systems
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kurman, M.
Right arrow Articles by Argyris, T. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kurman, M.
Right arrow Articles by Argyris, T. S.

American Journal of Pathology, Vol 79, 301-310, Copyright © 1975 by American Society for Investigative Pathology

REGULAR ARTICLES

The proliferative response to epidermis of hairless mice to full thickness wounds

M Kurman and TS Argyris

The healing of full thickness surgical wounds from 0 to 14 days has been studied in hairless mice. Within 2 days after wounding the surrounding epidermis is thickened and primarily composed of enlarged basophilic cells. The remnants of the hair follicles attached to the epidermis are converted into cords of enlarged basophilic cells. Epidermal thickening is maximum at 7 days. Associated with the epidermal thickening surrounding the wound edge is an increase in the total number of cells in the stratum granulosum and in the stratum spinosum. The number of basal cells does not change. Mitotic activity and mitotic rate increase within 1 day after wounding. Both reach their peaks by approximately 5 to 7 days and then begin to return to control levels. Mitotic duration does not change.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1975 by the American Society for Investigative Pathology.