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American Journal of Pathology, Vol 79, 453-464, Copyright © 1975 by American Society for Investigative Pathology

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Experimentally induced malakoplakia

Z Csapo, E Kuthy, J Lantos and J Ormos

Malakoplakia was induced experimentally by introducing large amounts of crude endotoxin-antigen comples of 075 Escherichia coli (E. coli 12797 CDC 0 group 75) into the kidneys and testes of rats. First leukocytes, then granulation tissue composed mainly of characteristic macrophages, the so-called Hansemann cells, appeared around the endotoxin-antigen mass. On the eighth day following the injection, deposition of calcium phosphate into the cytosegresomes of macrophages began and acused the formation of the Michaelis-Gutmann bodies necessary for the diagnosis of malakoplakia. The induction of the same process in humans by E coli endotoxin seems to be possible.




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Copyright © 1975 by the American Society for Investigative Pathology.