help button home button Am J Pathol Angiogenesis Meeting
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brunning, R. D.
Right arrow Articles by Parkin, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brunning, R. D.
Right arrow Articles by Parkin, J.

American Journal of Pathology, Vol 79, 565-578, Copyright © 1975 by American Society for Investigative Pathology

REGULAR ARTICLES

Ribosome-lamella complexes in neoplastic hematopoietic cells

RD Brunning and J Parkin

The ultrastructural cellular inclusions referred to as ribosome-lamella complexes were observed in the neoplastic cell population of 4 patients with three types of hematopoietic malignancy, monoblastic leukemia. Waldenstrom's macroglobulinemia, and chronic lymphatic leukemia. The ultrastructural characteristics of the inclusions were similar in the 4 cases. The percentage of cells affected ranged from approximately 90% in 1 patient with monoblastic leukemia to approximately 10% in a patient with Waldenstrom's macroglobulinemia. The complexes appeared to originate from the rough endoplasmic reticulum. Observations suggested a developmental sequence beginning with aggregate strands of rough endoplasmic reticulum, subsequent alignment of the strands of rough endoplasmic reticulum in a concentric configuration, followed by maturation to fully developed ribosome-lamella complexes. Although the ribosome-lamella complex has been found in the neoplastic cells of several patients with leukemic reticuloendotheliosis ("hairy cell leukemia"), its occurrence in these three different hematopoietic disorders indicates a lack of diagnostic specificity of this structure.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1975 by the American Society for Investigative Pathology.