This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kaplan, C. Articles by Gallo, G. Search for Related Content PubMed PubMed Citation Articles by Kaplan, C. Articles by Gallo, G.

American Journal of Pathology, Vol 80, 227-234, Copyright © 1975 by American Society for Investigative Pathology

REGULAR ARTICLES

Age-related incidence of sclerotic glomeruli in human kidneys

C Kaplan, B Pasternack, H Shah and G Gallo

The incidence of sclerotic glomeruli as a function of age in kidneys from 122 patients without clinical evidence of renal disease or hypertension was estimated by histologic quantitation. Based on statistical analysis of data from this sample, 95% of the normal population up to 40 years of age would be expected to have less than 10% sclerotic glomeruli. After the age of 40 years, the upper limit containing 95% of the normal population exceeds 10% sclerosis, and after the age of 50, there is a broad scatter of observed percentage of sclerotic glomeruli. These findings suggest that, in patients 40 years of age and younger, sclerosis of glomeruli at an incidence greater than 10% is disease-related, while in patients older than 40 years (and particularly those older than 50), there is a transition, and the distinction between abiotrophic involutional sclerosis and disease- related sclerosis becomes less clear.

This article has been cited by other articles:

				F. Inserra, N. Basso, M. Ferder, M. Userpater, I. Stella, N. Paglia, P. Inserra, D. Tenembaum, and L. Ferder Changes seen in the aging kidney and the effect of blocking the renin--angiotensin system Therapeutic Advances in Cardiovascular Disease, October 1, 2009; 3(5): 341 - 346. [Abstract] [PDF]

				H. N. Ibrahim, R. Foley, L. Tan, T. Rogers, R. F. Bailey, H. Guo, C. R. Gross, and A. J. Matas Long-Term Consequences of Kidney Donation N. Engl. J. Med., January 29, 2009; 360(5): 459 - 469. [Abstract] [Full Text] [PDF]

				J. E. Wiggins, M. Goyal, S. K. Sanden, B. L. Wharram, K. A. Shedden, D. E. Misek, R. D. Kuick, and R. C. Wiggins Podocyte Hypertrophy, "Adaptation," and "Decompensation" Associated with Glomerular Enlargement and Glomerulosclerosis in the Aging Rat: Prevention by Calorie Restriction J. Am. Soc. Nephrol., October 1, 2005; 16(10): 2953 - 2966. [Abstract] [Full Text] [PDF]

				G. C. Hard and Kanwar Nasir Khan Invited Review: A Contemporary Overview of Chronic Progressive Nephropathy in the Laboratory Rat, and Its Significance for Human Risk Assessment Toxicol Pathol, February 1, 2004; 32(2): 171 - 180. [Abstract] [PDF]

				S. K. Sanden, J. E. Wiggins, M. Goyal, L. K. Riggs, and R. C. Wiggins Evaluation of a Thick and Thin Section Method for Estimation of Podocyte Number, Glomerular Volume, and Glomerular Volume Per Podocyte in Rat Kidney with Wilms' Tumor-1 Protein Used as a Podocyte Nuclear Marker J. Am. Soc. Nephrol., October 1, 2003; 14(10): 2484 - 2493. [Abstract] [Full Text] [PDF]

				S. LIU, J. LUTZ, B. ANTUS, Y. YAO, S. BAIK, F. ILLIES, and U. HEEMANN Recipient Age and Weight Affect Chronic Renal Allograft Rejection in Rats J. Am. Soc. Nephrol., August 1, 2001; 12(8): 1742 - 1749. [Abstract] [Full Text] [PDF]

				R. E. Tracy and T. Ishii What is 'nephrosclerosis'? Lessons from the US, Japan, and Mexico Nephrol. Dial. Transplant., September 1, 2000; 15(9): 1357 - 1366. [Abstract] [Full Text] [PDF]

				E. Pokorna, S. Vitko, M. Chadimova, and O. Schuck Adverse effect of donor arteriolosclerosis on graft outcome after renal transplantation Nephrol. Dial. Transplant., May 1, 2000; 15(5): 705 - 710. [Abstract] [Full Text] [PDF]

				B. F. Culleton, M. G. Larson, J. C. Evans, P. W. F. Wilson, B. J. Barrett, P. S. Parfrey, and D. Levy Prevalence and Correlates of Elevated Serum Creatinine Levels: The Framingham Heart Study Arch Intern Med, August 9, 1999; 159(15): 1785 - 1790. [Abstract] [Full Text] [PDF]

				G. M. Chertow, E. L. Milford, H. S. Mackenzie, and B. M. Brenner Antigen-Independent Determinants of Cadaveric Kidney Transplant Failure JAMA, December 4, 1996; 276(21): 1732 - 1736. [Abstract] [PDF]

				H. Schnaper, J. Kopp, A. Poncelet, S. Hubchak, W. Stetler-Stevenson, P. Klotman, and H. Kleinman Increased expression of extracellular matrix proteins and decreased expression of matrix proteases after serial passage of glomerular mesangial cells J. Cell Sci., January 10, 1996; 109(10): 2521 - 2528. [Abstract] [PDF]

				A. L. Buchman, A. Moukarzel, M. E. Ament, J. Gornbein, B. Goodson, C. Carlson, and R. A. Hawkins Serious Renal Impairment Is Associated With Long-Term Parenteral Nutrition JPEN J Parenter Enteral Nutr, September 1, 1993; 17(5): 438 - 444. [Abstract] [PDF]

				R. J. Cody, S. Torre, M. Clark, and K. Pondolfino Age-Related Hemodynamic, Renal, and Hormonal Differences Among Patients With Congestive Heart Failure Arch Intern Med, May 1, 1989; 149(5): 1023 - 1028. [Abstract] [PDF]

				W. W. Brown, B. B. Davis, L. A. Spry, N. Wongsurawat, J. D. Malone, and D. T. Domoto Aging and the Kidney Arch Intern Med, September 1, 1986; 146(9): 1790 - 1796. [Abstract] [PDF]

				B. H. Brouhard The Role of Dietary Protein in Progressive Renal Disease Arch Pediatr Adolesc Med, July 1, 1986; 140(7): 630 - 637. [Abstract] [PDF]

				J. L. Blackshear, M. Davidman, and M. T. Stillman Identification of Risk for Renal Insufficiency From Nonsteroidal Anti-inflammatory Drugs Arch Intern Med, June 1, 1983; 143(6): 1130 - 1134. [Abstract] [PDF]

				T. W. MEYER, S. ANDERSON, and B. M. BRENNER Dietary Protein Intake and Progressive Glomerular Sclerosis: The Role of Capillary Hypertension and Hyperperfusion in the Progression of Renal Disease Ann Intern Med, May 1, 1983; 98(5_Part_2): 832 - 838. [Abstract] [PDF]