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American Journal of Pathology, Vol 80, 329-340, Copyright © 1975 by American Society for Investigative Pathology


REGULAR ARTICLES

Immune complex type glomerulonephritis in cirrhosis of the liver

P Callard, G Feldmann, D Prandi, MF Belair, C Mandet, Y Weiss, P Druet, JP Benhamou and J Bariety

Glomerular lesions were detected in 9 of 10 patients with liver cirrhosis: these lesions consisted of a) thickening of basement- membrane-like material, b) electron-dense deposits in mesangial areas and in capillary walls, c) round areas of rarefaction in the membrane- like material and in some deposits, and d) presence of IgA, with IgG and/or IgM and/or C3, in the deposits. The association of these four abnormalities seems to be characteristic of "cirrhotic glomerulonephritis." The deposits could be the result of precipitation in the glomeruli of either aggregated immunoglobulins or circulating immune complexes.


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Nephrol Dial TransplantHome page
A. D. Smet, D. Kuypers, P. Evenepoel, B. Maes, T. Messiaen, B. V. Damme, and Y. Vanrenterghem
Full house' positive immunohistochemical membranoproliferative glomerulonephritis in a patient with portosystemic shunt
Nephrol. Dial. Transplant., November 1, 2001; 16(11): 2258 - 2262.
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Copyright © 1975 by the American Society for Investigative Pathology.