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American Journal of Pathology, Vol 81, 163-178, Copyright © 1975 by American Society for Investigative Pathology

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Cell injury with viruses

I Tamm

The inhibitions of cellular protein and RNA synthesis in picornavirus- infected cells are early events which require only limited synthesis of virus-specific proteins. The inhibition of cellular protein synthesis appears to be due to blocking of the association of ribosomes with host messenger RNA. Inhibition of cellular RNA synthesis involves inactivation of the template-enzyme complex and affects ribosomal RNA synthesis before messenger RNA synthesis. Inhibition of cellular DNA synthesis also occurs early and may be secondary to inhibition of cellular protein synthesis. Early chromatid breaks may be related to inhibitions of cellular protein and nucleic acid synthesis. Stimulation of phospholipid synthesis in picornavirus-infected cells also requires only limited synthesis of virus-specific proteins. In contrast, release of lysosomal enzymes, proliferation of smooth cytoplasmic membranes, cellular vacuolization, retraction, and rounding, and diffuse chromosomal changes related to karyorrhexis and pyknosis are all dependent on considerable synthesis of virus-specific proteins during the middle part of the picornavirus growth cycle. The early virus- induced alterations in cellular biosynthetic processes are not the direct or sole cause of the subsequent marked pathologic changes in the membranes and chromosomes of the cell.