help button home button Am J Pathol sign up for etoc
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reynolds, E. S.
Right arrow Articles by Murphy, S. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reynolds, E. S.
Right arrow Articles by Murphy, S. D.

American Journal of Pathology, Vol 81, 219-236, Copyright © 1975 by American Society for Investigative Pathology

REGULAR ARTICLES

Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene. Role of mixed function oxidase system

ES Reynolds, MT Moslen, S Szabo, RJ Jaeger and SD Murphy

Vinyl chloride, an occupational carcinogen, produces acute liver injury in rats pretreated with phenobarbital or Aroclor 1254. Injury appears related to morphologic changes in the endoplasmic reticulum. The degree of injury, as indicated by elevation of serum enzymes derived from the liver, correlates with the magnitude of induction of cytochrome P-450 and its reduction by NADPH. Hepatic injury following 1,1- dichloroethylene exposure differs strikingly from that caused by vinyl chloride and appears to involve plasma membranes, mitochondria, and chromatin and spares endoplasmic reticulum. Induction of cytochrome P- 450 appears to protect against 1,1-dichloroethylene but not vinyl chloride.


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
E. J. Martin, W. J. Racz, and P.-G. Forkert
Mitochondrial Dysfunction Is an Early Manifestation of 1,1-Dichloroethylene-Induced Hepatotoxicity in Mice
J. Pharmacol. Exp. Ther., January 1, 2003; 304(1): 121 - 129.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
P.-G. Forkert and S. M. Boyd
Differential Metabolism of 1,1-Dichloroethylene in Livers of A/J, CD-1, and C57BL/6 Mice
Drug Metab. Dispos., November 1, 2001; 29(11): 1396 - 1402.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1975 by the American Society for Investigative Pathology.