help button home button Am J Pathol ASIP WHAT IS IT?
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Farber, J. L.
Right arrow Articles by El-Mofty, S. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Farber, J. L.
Right arrow Articles by El-Mofty, S. K.

American Journal of Pathology, Vol 81, 237-250, Copyright © 1975 by American Society for Investigative Pathology

REGULAR ARTICLES

The biochemical pathology of liver cell necrosis

JL Farber and SK El-Mofty

Cell death and necrosis are important reactions of liver cells to injury that play a role in a wide variety of human liver diseases. A review is given of the important facets known about the biochemical basis of toxic liver cell death. Liver cells can withstand a great many specific biochemical and morphologic changes without loss of viability. Disturbances in RNA and protein synthesis, mitochondrial function, or release of lysosomal enzymes do not play a primary causative role in cell death. Many previous studies have tended to implicate the plasma membrane and its presumed role in maintaining the proper Ca2+ balance as the primary site of the development of irreversible hepatocyte damage. These studies have generally faced a major difficulty in determining if the observed changes are the cause or an effect of cell death. Galactosamine-induced liver cell injury seems to offer a potentially analyzable model for the experimental analysis of liver cell necrosis. Our studies on the role of plasma membrane injury and associated increases in total cellular calcium are reviewed, and a tentative working hypothesis for the pathogenesis of galactosamine- induced liver cell necrosis is presented.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
M. Warny and C. P. Kelly
Monocytic cell necrosis is mediated by potassium depletion and caspase-like proteases
Am J Physiol Cell Physiol, March 1, 1999; 276(3): C717 - C724.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. Smith, H Thor, and S Orrenius
Toxic injury to isolated hepatocytes is not dependent on extracellular calcium
Science, September 11, 1981; 213(4513): 1257 - 1259.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1975 by the American Society for Investigative Pathology.