This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gondos, B. Search for Related Content PubMed PubMed Citation Articles by Gondos, B.

American Journal of Pathology, Vol 81, 303-321, Copyright © 1975 by American Society for Investigative Pathology

REGULAR ARTICLES

Surface epithelium of the developing ovary. Possible correlation with ovarian neoplasia

B Gondos

The surface epithelium of the fetal ovary undergoes diffuse proliferation during the fourth and fifth months of gestation, after which it reverts to a single layer separated from the developing cortex by a tunica albuginea. The proliferation is associated with marked nuclear irregularity and pleomorphism similar to that seen in surface epithelial neoplasms. The epithelial changes occur during the same time period that interstitial cells with ultrastructural and histochemical properties of steroid-secreting tissue appear in the ovarian stroma. The possible role of steroid hormones in stimulating surface epithelial proliferation is discussed.

This article has been cited by other articles:

				A. Lukanova and R. Kaaks Endogenous Hormones and Ovarian Cancer: Epidemiology and Current Hypotheses Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 98 - 107. [Abstract] [Full Text] [PDF]

				P. Roger, P. Pujol, A. Lucas, P. Baldet, and H. Rochefort Increased Immunostaining of Fibulin-1, an Estrogen-Regulated Protein in the Stroma of Human Ovarian Epithelial Tumors Am. J. Pathol., November 1, 1998; 153(5): 1579 - 1588. [Abstract] [Full Text] [PDF]