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American Journal of Pathology, Vol 81, 337-347, Copyright © 1975 by American Society for Investigative Pathology

REGULAR ARTICLES

The resistance of certain tissues to invasion. III. Cartilage extracts inhibit the growth of fibroblasts and endothelial cells in culture

R Eisenstein, KE Kuettner, C Neapolitan, LW Soble and N Sorgente

Extracts of bovine dermis and cartilage inhibit the growth of bovine endothelial cells more than that of most of the fibroblast types tested. Extracts of cartilage, a tissue rather resistant to invasion, inhibit the growth of endothelial cells more than extracts of dermis do. Since such extracts contain antiproteolytic activity, it is suggested that the inhibition of cell growth they induce is effected by protease inhibitors native to connective tissues.


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Copyright © 1975 by the American Society for Investigative Pathology.