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American Journal of Pathology, Vol 81, 545-560, Copyright © 1975 by American Society for Investigative Pathology

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Lipid content in the liver of fatty metamorphosis of pregnancy

JW Eisele, EA Barker and EA Smuckler

Lipid analyses were performed on the liver of a patient who died during an episode of acute fatty liver of pregnancy, and on livers from normal subjects and from subjects suffering from nutritional fatty livers. Comparison of these data indicates that in fatty liver of pregnancy the increased hepatic lipids consist primarily of free fatty acids. The recognized toxicity of fatty acids suggests a pathogenic mechanism for the disease. Nutritional fatty liver is associated predominantly with an increase in triglyceride. These changes are not the result of postmortem change, and they confirm and extend the previous data concerning the fat accumulation in human hepatic illness.


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 J Intensive Care MedHome page
H. White and M. Peters
Severe Liver Disease in Pregnancy
J Intensive Care Med, May 1, 1990; 5(3): 104 - 109.
[Abstract] [PDF]


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Copyright © 1975 by the American Society for Investigative Pathology.