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American Journal of Pathology, Vol 83, 245-254, Copyright © 1976 by American Society for Investigative Pathology

REGULAR ARTICLES

Unusual intranuclear filaments in the circulating lymphocytes of patients with multiple sclerosis and optic neuritis

R Tanaka, D Santoli and H Koprowski

Mononuclear cells obtained from the peripheral blood of patients with multiple sclerosis (MS) and optic neuritis (ON) were examined by electron microscopy. Unusual intranuclear filaments identical with the so-called paramyxovirus-like filaments were found in circulating lymphocytes from 5 patients with MS and 3 with ON. They were observed in 0.1 to 0.5% of the mononuclear cells. Electron microscopy of the blood cells from 5 other patients with ON, 3 patients with neurologic diseases other than MS, and 4 normal subjects failed to reveal similar structures. The filaments were also absent from blood cells from blood cells from normal subjects during the process of autolysis.




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Copyright © 1976 by the American Society for Investigative Pathology.