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American Journal of Pathology, Vol 83, 299-318, Copyright © 1976 by American Society for Investigative Pathology

REGULAR ARTICLES

Effects of amyloid induction on plasma protein turnover, and its implication

R Kisilevsky, M Axelrad, S Brunet and M Richards

Using polyacrylamide gel electrophoresis and radioiodinated plasma proteins, data on the rate constant for synthesis and fractional degradation rates for albumin, alpha1-, alpha2-, beta-, and gamma- globulins were obtained during accelerated amyloid induction in a murine model. The results indicate that during amyloid induction there is an increased rate of synthesis of alpha2-, beta-, and gamma- globulins but only the alpha2-globulin degradation rate is accelerated. In this experimental system, should amyloid protein be a degradation product of a plasma fraction, the alpha2-globulin appears as the most likely precursor. The implications of our findings are discussed, and a new general mechanism of amyloid production is proposed.




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Copyright © 1976 by the American Society for Investigative Pathology.