This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Strauss, R. H. Articles by Hayes, J. A. Search for Related Content PubMed PubMed Citation Articles by Strauss, R. H. Articles by Hayes, J. A.

American Journal of Pathology, Vol 84, 561-578, Copyright © 1976 by American Society for Investigative Pathology

REGULAR ARTICLES

Acute lung injury induced by cadmium aerosol. I. Evolution of alveolar cell damage

RH Strauss, KC Palmer and JA Hayes

Following exposure to an aerosol of 0.1% (.005 M) cadmium chloride, rat lungs were examined at 6 hours and 1, 2, 3, 4, 7, and 10 days. By light microscopy, damage was multifocal and centered about respiratory bronchioles. Ultrastructurally, there was Type 1 cell edema with frequent loss of surface plasma membranes during the first 24 hours. After 2 days, the number of Type 2 cells had markedly increased, and by 3 days the damaged alveoli were lined by plump cuboidal cells closely resembling Type 2 cells. By 4 days, these cells were flatter, the change being more marked by 7 days; by 10 days, the cells had regained the appearance of Type 1 cells through loss of osmiophilic bodies and superficial microvilli. We conclude that CdCl2 damages Type 1 cells, which are then replaced by proliferation of Type 2 cells. These cells lose their osmiophilic bodies and flatten out to replace the lost Type 1 cells, the process being almost complete by 10 days after the injury. This pattern resembles the injury caused by NO2, O3, and O2.

This article has been cited by other articles:

				P. H. Wald and J. R. Balmes Respiratory Effects of Short-Term, High-Intensity Toxic Inhalations: Smoke, Gases, and Fumes J Intensive Care Med, September 1, 1987; 2(5): 260 - 278. [Abstract] [PDF]