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American Journal of Pathology, Vol 85, 349-362, Copyright © 1976 by American Society for Investigative Pathology

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Mesangial involvement in hemolytic-uremic syndrome. A light and electron microscopic study

H Shigematsu, SH Dikman, J Churg, E Grishman and JL Duffy

Electron microscopic analysis of the mesangial injury in the hemolytic- uremic syndrome was performed in 10 patients. Proteinaceous material similar to that found in the subendothelial region was also seen focally in the mesangium altering the matrix and imparting a reticular appearance. This degenerative process was associated with reparative changes in the glomerular tuft. Many of the mesangial cells were hypertrophied and demonstrated phagocytic activity and peripheral extension of their cytoplasmic processes. Mitotic figures in endothelial as well as mesangial cells were regarded as evidence of a reparative process. Severe mesangial insudation of material containing fibrinogen derivatives resulted in segmental tuft necrosis with almost complete replacement and destruction of the mesangial matrix. On some occasions, a break of the glomerular basement membrane was accompanied by the escape of intraluminal contents into the urinary space, leading to crescentic epithelial cell proliferation.