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American Journal of Pathology, Vol 87, 1-18, Copyright © 1977 by American Society for Investigative Pathology

REGULAR ARTICLES

Immunopathology of early and clinically silent lupus nephropathy

T Cavallo, WR Cameron and D Lapenas

Detailed immunopathologic studies of early or silent renal alterations in systemic lupus erythematosus have been sparse. The renal biopsies of 16 lupus patients with normal renal function, including 8 with hematuria and/or proteinuria of recent onset, and 8 without clinically detectable renal disease were investigated by light, immunofluorescence, and electron microscopy. Immunoglobulins, complement components, and electron-dense deposits were detected in glomeruli of all patients, regardless of morphologic appearance or lack of clinical evidence of renal involvement. Features of membranous glomerulonepritis were observed in 4 patients with substantial proteinuria. In the remaining 12 patients, including 3 with hematuria and 4 with slight proteinuria, either minimal glomerular alterations or features of mesangial proliferative glomerulonephritis were seen. Transformation of the original disease was demonstrated in 3 of 3 patients rebiopsied within 2 years. The significance of these findings is discussed in relation to a) the spectrum of clinical and immunopathologic alterations in lupus nephritis and b) transformation of the original disease.


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M E Zabaleta-Lanz, L E Munoz, F J Tapanes, R E Vargas-Arenas, I Daboin, Y Barrios, J A Pinto, and N E Bianco
Further description of early clinically silent lupus nephritis
Lupus, December 1, 2006; 15(12): 845 - 851.
[Abstract] [PDF]


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Copyright © 1977 by the American Society for Investigative Pathology.