This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cattell, V. Articles by Bradfield, J. W. Search for Related Content PubMed PubMed Citation Articles by Cattell, V. Articles by Bradfield, J. W.

American Journal of Pathology, Vol 87, 511-524, Copyright © 1977 by American Society for Investigative Pathology

REGULAR ARTICLES

Focal mesangial proliferative glomerulonephritis in the rat caused by habu snake venom. A morphologic study

V Cattell and JW Bradfield

A new model of focal mesangial proliferative glomerulonephritis in the rat has been produced by intravenous habu snake venom. Glomerulonephritis developed in 70% of rats surviving the first 6 hours after venom administration. The earliest ultrastructural change (10 minutes after venom) was the presence of loose platelet aggregates and free granules in the capillary lumen and mesangium. This was followed by dissolution of the matrix and endothelial damage. Between 4 and 24 hours, a characteristic focal and segmental ballooned lesion of glomerular capillaries developed. In these lesions, from 3 days onwards a segmental mesangial proliferation occurred, which persisted until sacrifice at 21 days.

This article has been cited by other articles:

				H. Takahara, I. Shirato, K. Asanuma, M. Yamashita, Y. Takeda, and Y. Tomino Tensin Is Expressed in Glomerular Mesangial Cells and Is Related to Their Attachment to Surrounding Extracellular Matrix J. Histochem. Cytochem., May 1, 2004; 52(5): 683 - 692. [Abstract] [Full Text] [PDF]