This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Levitt, M. H. Articles by Newkirk, C. Search for Related Content PubMed PubMed Citation Articles by Levitt, M. H. Articles by Newkirk, C.

American Journal of Pathology, Vol 88, 5-28, Copyright © 1977 by American Society for Investigative Pathology

REGULAR ARTICLES

Experimental pancreatic carcinogenesis. I. Morphogenesis of pancreatic adenocarcinoma in the Syrian golden hamster induced by N-nitroso-bis(2- hydroxypropyl)amine

MH Levitt, CC Harris, R Squire, S Springer, M Wenk, C Mollelo, D Thomas, E Kingsbury and C Newkirk

In serial sacrifice experiment, outbred male Syrian golden hamsters were treated once weekly for life with subcutaneous injections of N- nitroso-bis(2-hydroxypropyl) amine (DIPN). The pancreas was examined by high resolution light (1-micro sections) and transmission electron microscopy. Early nonspecific changes in all pancreatic epithelial cellular elements were followed by a progressive proliferation of intra- and interlobular duct cells, with the development of multicentric foci of cystic and papillary cystic adenomas, intraductal carcinomas, and invasive ductal neoplasms. These observations were consistent with multistage morphogenesis of pancreatic adenocarcinoma of ductal origin.

This article has been cited by other articles:

				M Tascilar, B P van Rees, P D J Sturm, G N J Tytgat, R H Hruban, S N Goodman, F M Giardiello, G J A Offerhaus, and A C Tersmette Pancreatic cancer after remote peptic ulcer surgery J. Clin. Pathol., May 1, 2002; 55(5): 340 - 345. [Abstract] [Full Text] [PDF]