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American Journal of Pathology, Vol 89, 555-574, Copyright © 1977 by American Society for Investigative Pathology

REGULAR ARTICLES

Immunohistochemical and ultrastructural analysis of medullary carcinoma of the thyroid in relation to hormone production

T Kameya, Y Shimosato, I Adachi, K Abe, N Kasai, K Kimura and K Baba

Eighteen cases of medullary carcinoma of the thyroid were analyzed immunohistochemically for calcitonin- and ACTH-containing cells, and tumor cells in 8 cases were examined by an electron microscope and analyzed by manual and computer procedures with particular attention paid to the size and quality of secretory granules. Calcitonin- and ACTH-containing cells were found singly or in clusters in 14 and 11 tumors, respectively. In 4 cases, calcitonin-positive cell clusters and an increase in number of singly scattered C cells were seen apart from the main tumor, suggesting a multicentric nature of certain medullary carcinomas. Some ACTH-containing cells were apparently also positive for calcitonin. In a case of familial Sipple disease, follicular lining cells were replaced in areas with ACTH-containing cells. Three to five frequency distribution curves of the size of secretory granules were obtained in all of 6 cases analyzed, and at least two different types of granule matrix were identified.




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Copyright © 1977 by the American Society for Investigative Pathology.