help button home button Am J Pathol International Conference on Pathology of Chest Diseases
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sale, G. E.
Right arrow Articles by Thomas, E. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sale, G. E.
Right arrow Articles by Thomas, E. D.

American Journal of Pathology, Vol 89, 621-635, Copyright © 1977 by American Society for Investigative Pathology

REGULAR ARTICLES

The skin biopsy in the diagnosis of acute graft-versus-host disease in man

GE Sale, KG Lerner, EA Barker, HM Shulman and ED Thomas

Criteria for diagnosis of acute graft-versus-host disease (GVHD) using skin biopsies were derived from a) general experience with more than 300 human marrow grafts and b) the results of "blind" studies of skin biopsy specimens of patients grafted with either allogeneic or syngeneic marrow. Large doses of cytotoxic drugs and irradiation given before grafting can produce transient skin changes interfering significantly with the diagnosis of GVHD. Artifacts can also cause difficulty. Epidermal cytologic atypia, dyskeratosis, and satellitosis were present both in allografted patients with acute clinical GVHD of multiple systems and in patients given autologous or syngeneic marrow. Due to the marked overlap in histopathologic findings between these two types of skin injury, frequent serial skin biopsies must be combined with all other available clinical and biopsy data to provide reliable diagnosis of acute GVHD in man.


This article has been cited by other articles:


Home page
 Arch DermatolHome page
Y. Zhou, M. J. Barnett, and J. K. Rivers
Clinical Significance of Skin Biopsies in the Diagnosis and Management of Graft-vs-Host Disease in Early Postallogeneic Bone Marrow Transplantation
Arch Dermatol, June 1, 2000; 136(6): 717 - 721.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y. Ilan, I. Gotsman, M. Pines, R. Beinart, M. Zeira, M. Ohana, E. Rabbani, D. Engelhardt, and A. Nagler
Induction of oral tolerance in splenocyte recipients toward pretransplant antigens ameliorates chronic graft versus host disease in a murine model
Blood, June 1, 2000; 95(11): 3613 - 3619.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
L. M WILLIAMSON
Transfusion associated graft versus host disease and its prevention
Heart, September 1, 1998; 80(3): 211 - 212.
[Full Text]

Home page
 Arch DermatolHome page
S. Aractingi and O. Chosidow
Cutaneous Graft-versus-Host Disease
Arch Dermatol, May 1, 1998; 134(5): 602 - 612.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1977 by the American Society for Investigative Pathology.