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American Journal of Pathology, Vol 91, 49-55, Copyright © 1978 by American Society for Investigative Pathology

REGULAR ARTICLES

Effect of cycloheximide on glucagon-induced autophagy. Quantitative examinations on hepatocytes in the rat

HJ Rumpelt and T Weisbach

By means of fine structural evaluation, a highly significant inhibitory effect of cycloheximide (20 mg/kg) on glucagon-induced autophagy is demonstrated in rat hepatocytes, which also presumably affects physiologic autophagic activities. Contrary to other investigators, we think in vivo global inhibition experiments using cycloheximide as an inhibitor of protein synthesis do not provide substantial information on the origin of the segregating membranes.




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Copyright © 1978 by the American Society for Investigative Pathology.