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American Journal of Pathology, Vol 91, 355-360, Copyright © 1978 by American Society for Investigative Pathology

REGULAR ARTICLES

Renal lesions induced induced by tilorone and an analog. Ultrastructure and acid phosphatase study

WL Thelmo and S Levine

Tilorone, 2,7-bis-(diethylaminoethoxy)-fluoren-9-one hydrochloride, an interferon inducer, has been shown to cause hydropic degeneration in choroid plexus and distal convoluted tubules of kidney. Ultrastructural and histochemical studies of the renal lesion produced by tilorone and one of its analogs revealed striking accumulation of vacuoles and/or acid-phosphatase-positive lemellar bodies retricted to glomeruli, ascending limb of Henle's loop, and distal convoluted tubules.


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Copyright © 1978 by the American Society for Investigative Pathology.