This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Montfort, I. Articles by Perez-Tamayo, R. Search for Related Content PubMed PubMed Citation Articles by Montfort, I. Articles by Perez-Tamayo, R.

American Journal of Pathology, Vol 92, 411-420, Copyright © 1978 by American Society for Investigative Pathology

REGULAR ARTICLES

Collagenase in experimental carbon tetrachloride cirrhosis of the liver

I Montfort and R Perez-Tamayo

The presence and distribution of collagenase in experimental CCl4 cirrhosis of the liver in rats has been studied by immunohistochemical techniques. A monospecific anti-rat uterus collagenase antibody was raised in rabbits and used for indirect immunofluorescence staining of liver sections obtained from rats in both the reversible and irreversible stages of CCl4-induced cirrhosis. Collagenase is present assoicated with connective tissue septums as long as cirrhosis is reversible, and it is not detectable in the irreversible stage. In animals sacrificed during the transition between the reversible and irreversible stages of cirrhosis, collagenase appeared bound to the outer surfaces of connective tissue septums and was absent from the deeper portions. These observation suggest that the irreversibility of experimental CCl4 cirrhosis of the liver is associated with a disturbance in the mechanisms of collagen degradation, which may be a deficiency in collagenase activity, a change in the susceptibility of the substrate, or a combination of both factors.

This article has been cited by other articles:

				N. Meraz-Cruz, A. Ortega, G. Estrada-Gutierrez, A. Flores, A. Espejel, C. Hernandez-Guerrero, and F. Vadillo-Ortega Identification of a calcium-dependent matrix metalloproteinase complex in rat chorioallantoid membranes during labour Mol. Hum. Reprod., October 1, 2006; 12(10): 633 - 641. [Abstract] [Full Text] [PDF]

				C. G. Lechuga, Z. H. Hernandez-Nazara, J.-A. D. Rosales, E. R. Morris, A. R. Rincon, A. M. Rivas-Estilla, A. Esteban-Gamboa, and M. Rojkind TGF-{beta}1 modulates matrix metalloproteinase-13 expression in hepatic stellate cells by complex mechanisms involving p38MAPK, PI3-kinase, AKT, and p70S6k Am J Physiol Gastrointest Liver Physiol, November 1, 2004; 287(5): G974 - G987. [Abstract] [Full Text] [PDF]

				C Thirunavukkarasu, Y Yang, V M Subbotin, S A K Harvey, J Fung, and C R Gandhi Endothelin receptor antagonist TAK-044 arrests and reverses the development of carbon tetrachloride induced cirrhosis in rats Gut, July 1, 2004; 53(7): 1010 - 1019. [Abstract] [Full Text] [PDF]

				R C BENYON and J P IREDALE Is liver fibrosis reversible? Gut, April 1, 2000; 46(4): 443 - 446. [Full Text] [PDF]