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American Journal of Pathology, Vol 93, 499-513, Copyright © 1978 by American Society for Investigative Pathology

REGULAR ARTICLES

Tumor-induced immunosuppression

H Friedman, S Specter, M Watanabe and SH Pan

Three tumor systems, including a mastocytoma, plasmacytomas, and a leukemia-lymphoma were studied for their ability to modify humoral immunity to sheep erythrocytes both in vivo and in vitro. All tumors resulted in a depression of the hemolytic antibody plaque-forming cell response in susceptible mice. These studies indicated that the mechanism(s) of suppression, although not fully defined, were different for each model system investigated.




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Copyright © 1978 by the American Society for Investigative Pathology.