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American Journal of Pathology, Vol 93, 745-752, Copyright © 1978 by American Society for Investigative Pathology

REGULAR ARTICLES

Ultrastructural localization of phospholipases in the Clara cell of the rat bronchiole

K Yoneda

The Clara cell of the bronchiole is unique to the lung; the cell's function is not clear. The localization of the lipid-hydrolase enzymes phospholipase, lysophospholipase, and lipase was examined ultrastructurally in the Clara cell of the rat bronchiole. The secretory granules of the Clara cell showed a strong reaction of lysophospholipase and a weak reaction of lipase. Phospholipase activity was not detected intracellularly. These findings suggest that the Clara cell secretes lipase-phospholipase into the bronchiolar lumen, thus catabolizing the pulmonary surfactant phospholipids.

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