| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
American Journal of Pathology, Vol 95, 117-130, Copyright © 1979 by American Society for Investigative Pathology
REGULAR ARTICLES |
RS Thrall, JR McCormick, RM Jack, RA McReynolds and PA Ward
A model for pulmonary fibrosis in the rat has been developed using intratracheal administration of bleomycin. The histopathologic features of the reaction are similar to those reported in the hamster model. Increases in vascular permeability are seen in the lung within 24 hours and persist over a 2-month period. Extractable collagen, as measured by hydroxyproline, increases during this time by a factor greater than 1.5 times the reference control values of normal lung. During this same period, a prominent eosinophilia develops. The continued treatment of bleomycin-injected rats with indomethacin markedly diminishes the amount of extractable lung collagen at 60 days and the histopathologic evidence of pulmonary fibrosis. The eosinophilia over the first 3 weeks is also markedly suppressed. Less dramatic effects were seen with the permeability changes. These findings indicate that the rat is a reliable and useful model for the study of blemoycin-induced pulmonary fibrosis and that treatment with indomethacin ameliorates the lung changes.
This article has been cited by other articles:
 |
|
 |
|
  B. B. Moore and C. M. Hogaboam Murine models of pulmonary fibrosis Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L152 - L160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Driehuys, G. P. Cofer, J. Pollaro, J. B. Mackel, L. W. Hedlund, and G. A. Johnson Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI PNAS, November 28, 2006; 103(48): 18278 - 18283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Kapoun, N. J. Gaspar, Y. Wang, D. Damm, Y.-W. Liu, G. O'Young, D. Quon, A. Lam, K. Munson, T.-T. Tran, et al. Transforming Growth Factor-beta Receptor Type 1 (TGFbetaRI) Kinase Activity but Not p38 Activation Is Required for TGFbetaRI-Induced Myofibroblast Differentiation and Profibrotic Gene Expression Mol. Pharmacol., August 1, 2006; 70(2): 518 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Arras, J. Louahed, V. Simoen, V. Barbarin, P. Misson, S. van den Brule, M. Delos, L. Knoops, J.-C. Renauld, D. Lison, et al. B Lymphocytes Are Critical for Lung Fibrosis Control and Prostaglandin E2 Regulation in IL-9 Transgenic Mice Am. J. Respir. Cell Mol. Biol., May 1, 2006; 34(5): 573 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Arras, J. Louahed, J.-F. Heilier, M. Delos, F. Brombacher, J.-C. Renauld, D. Lison, and F. Huaux IL-9 Protects against Bleomycin-Induced Lung Injury: Involvement of Prostaglandins Am. J. Pathol., January 1, 2005; 166(1): 107 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Williams, D. Malarkey, L. Cohn, D. Patrick, J. Dye, and G. Toews Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: Morphology and Ultrastructural Evidence for a Type II Pneumocyte Defect Chest, June 1, 2004; 125(6): 2278 - 2288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Otsuka, H Takahashi, M Shiratori, H Chiba, and S Abe Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist Thorax, January 1, 2004; 59(1): 31 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gunther, N. Lubke, M. Ermert, R. T. Schermuly, N. Weissmann, A. Breithecker, P. Markart, C. Ruppert, K. Quanz, L. Ermert, et al. Prevention of Bleomycin-induced Lung Fibrosis by Aerosolization of Heparin or Urokinase in Rabbits Am. J. Respir. Crit. Care Med., December 1, 2003; 168(11): 1358 - 1365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Adachi, M. Suzuki, T. Sugimoto, K. Yorozu, H. Takai, K. Uetsuka, H. Nakayama, and K. Doi Effects of Granulocyte Colony-Stimulating Factor (G-CSF) on Bleomycin-Induced Lung Injury of Varying Severity Toxicol Pathol, October 1, 2003; 31(6): 665 - 673. [Abstract] [PDF]
|
|
|
|
|
|
M. Endo, S. Oyadomari, Y. Terasaki, M. Takeya, M. Suga, M. Mori, and T. Gotoh Induction of arginase I and II in bleomycin-induced fibrosis of mouse lung Am J Physiol Lung Cell Mol Physiol, August 1, 2003; 285(2): L313 - L321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Charbeneau, P. J. Christensen, C. J. Chrisman, R. Paine III, G. B. Toews, M. Peters-Golden, and B. B. Moore Impaired synthesis of prostaglandin E2 by lung fibroblasts and alveolar epithelial cells from GM-CSF-/- mice: implications for fibroproliferation Am J Physiol Lung Cell Mol Physiol, June 1, 2003; 284(6): L1103 - L1111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P. Jankov, X. Luo, P. Demin, R. Aslam, V. Hannam, A. K. Tanswell, and C. R. Pace-Asciak Hepoxilin Analogs Inhibit Bleomycin-Induced Pulmonary Fibrosis in the Mouse J. Pharmacol. Exp. Ther., May 1, 2002; 301(2): 435 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Okamoto, S. Kato, K. Oizumi, M. Kinoshita, Y. Inoue, K. Hoshino, S. Akira, A. N. J. Mckenzie, H. A. Young, and T. Hoshino Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia Blood, February 15, 2002; 99(4): 1289 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-D. WANG, M. YAMAYA, S. OKINAGA, Y.-X. JIA, M. KAMANAKA, H. TAKAHASHI, L.-Y. GUO, T. OHRUI, and H. SASAKI Bilirubin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats Am. J. Respir. Crit. Care Med., February 1, 2002; 165(3): 406 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. PETERS-GOLDEN, M. BAILIE, T. MARSHALL, C. WILKE, S. H. PHAN, G. B. TOEWS, and B. B. MOORE Protection from Pulmonary Fibrosis in Leukotriene-Deficient Mice Am. J. Respir. Crit. Care Med., January 15, 2002; 165(2): 229 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. B. Moore, R. Paine III, P. J. Christensen, T. A. Moore, S. Sitterding, R. Ngan, C. A. Wilke, W. A. Kuziel, and G. B. Toews Protection from Pulmonary Fibrosis in the Absence of CCR2 Signaling J. Immunol., October 15, 2001; 167(8): 4368 - 4377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. BORZONE, R. MORENO, R. URREA, M. MENESES, M. OYARZUN, and C. LISBOA Bleomycin-Induced Chronic Lung Damage Does Not Resemble Human Idiopathic Pulmonary Fibrosis Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1648 - 1653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. EBIHARA, N. VENKATESAN, R. TANAKA, and M. S. LUDWIG Changes in Extracellular Matrix and Tissue Viscoelasticity in Bleomycin-induced Lung Fibrosis . Temporal Aspects Am. J. Respir. Crit. Care Med., October 1, 2000; 162(4): 1569 - 1576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. B. Moore, M. J. Coffey, P. Christensen, S. Sitterding, R. Ngan, C. A. Wilke, R. McDonald, S. M. Phare, M. Peters-Golden, R. Paine III, et al. GM-CSF Regulates Bleomycin-Induced Pulmonary Fibrosis Via a Prostaglandin-Dependent Mechanism J. Immunol., October 1, 2000; 165(7): 4032 - 4039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Christensen, M. B. Bailie, R. E. Goodman, A. D. O'Brien, G. B. Toews, and R. Paine III Role of diminished epithelial GM-CSF in the pathogenesis of bleomycin-induced pulmonary fibrosis Am J Physiol Lung Cell Mol Physiol, September 1, 2000; 279(3): L487 - L495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wang, O. Ibarra-Sunga, L. Verlinski, R. Pick, and B. D. Uhal Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor Am J Physiol Lung Cell Mol Physiol, July 1, 2000; 279(1): L143 - L151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. SATO, Y. SUZUKI, K. NISHIO, K. SUZUKI, K. NAOKI, K. TAKESHITA, H. KUDO, N. MIYAO, H. TSUMURA, H. SERIZAWA, et al. Roles of ICAM-1 for Abnormal Leukocyte Recruitment in the Microcirculation of Bleomycin-induced Fibrotic Lung Injury Am. J. Respir. Crit. Care Med., May 1, 2000; 161(5): 1681 - 1688. [Abstract] [Full Text]
|
|
|
|
|
|
R. J. MASON, M. I. SCHWARZ, G. W. HUNNINGHAKE, and R. A. MUSSON Pharmacological Therapy for Idiopathic Pulmonary Fibrosis . Past, Present, and Future Am. J. Respir. Crit. Care Med., November 1, 1999; 160(5): 1771 - 1777. [Full Text]
|
|
|
|
|
|
P. J. Christensen, R. E. Goodman, L. Pastoriza, B. Moore, and G. B. Toews Induction of Lung Fibrosis in the Mouse by Intratracheal Instillation of Fluorescein Isothiocyanate Is Not T-Cell-Dependent Am. J. Pathol., November 1, 1999; 155(5): 1773 - 1779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Okudela, T. Ito, H. Mitsui, H. Hayashi, N. Udaka, M. Kanisawa, and H. Kitamura The Role of p53 in Bleomycin-Induced DNA Damage in the Lung : A Comparative Study with the Small Intestine Am. J. Pathol., October 1, 1999; 155(4): 1341 - 1351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. N. Iyer, G. Gurujeyalakshmi, and S. N. Giri Effects of Pirfenidone on Procollagen Gene Expression at the Transcriptional Level in Bleomycin Hamster Model of Lung Fibrosis J. Pharmacol. Exp. Ther., April 1, 1999; 289(1): 211 - 218. [Abstract] [Full Text]
|
|
|
|
|
|
P. Teder and P. Heldin Mechanism of Impaired Local Hyaluronan Turnover in Bleomycin-induced Lung Injury in Rat Am. J. Respir. Cell Mol. Biol., September 1, 1997; 17(3): 376 - 385. [Abstract] [Full Text]
|
|
|
|
|
|
T. Pan, L. D. Nielsen, M. J. Allen, K. M. Shannon, J. M. Shannon, M. Selman, and Robert. J. Mason Serum SP-D is a marker of lung injury in rats Am J Physiol Lung Cell Mol Physiol, April 1, 2002; 282(4): L824 - L832. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
