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American Journal of Pathology, Vol 95, 339-346, Copyright © 1979 by American Society for Investigative Pathology

REGULAR ARTICLES

Delay in growth and the development of nephritis in rats treated with interferon preparations in the neonatal period

I Gresser, L Morel-Maroger, F Chatelet, C Maury, M Tovey, MT Bandu, J Buywid and M Delauche

Suckling rats were injected for 14 to 17 days with potent rat-cell- culture interferon preparations or various heterologous interferon or control preparations. Only treatment with rat interferon resulted in a delay in growth and maturation of different organs and the subsequent development of an "immune complex" type nephritis. Thus, 38 of 43 rats treated with rat interferon developed a severe glomerulonephritis. Thus, 38 of 43 rats treated with rat interferon developed a severe glomerulonephritis, whereas only 3 of 99 rats in the various control groups had minimal renal lesions. Deposits of IgG and C3 along the glomerular basement membrane were only seen in interferon-treated rats.




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Copyright © 1979 by the American Society for Investigative Pathology.