This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rappaport, H. Articles by Mathe, G. Search for Related Content PubMed PubMed Citation Articles by Rappaport, H. Articles by Mathe, G.

American Journal of Pathology, Vol 96, 121-142, Copyright © 1979 by American Society for Investigative Pathology

REGULAR ARTICLES

Histopathologic sequence of events in adult mice undergoing lethal graft-versus-host reaction developed across H-2 and/or non-H-2 histocompatibility barriers

H Rappaport, A Khalil, O Halle-Pannenko, L Pritchard, D Dantchev and G Mathe

The sequence of histologic events in graft-versus-host reaction (GVHR) caused by major and/or minor histoincompatibilities was studied. It was discovered that GVHR may manifest itself in the form of two distinct multiphasic disease entities, depending on whether the donor cells are incompatible with the host for both major and minor histocompatibility antigens ("major GVHR") or for minor histocompatibility antigens alone ("minor GVHR"). The acute or major GVHR has four phases: 1) a transient phase of aplasia, 2) a repopulation phase, 3) a proliferative phase involving lymphoid, presumably immunocompetent, cells, and 4) a phase of acute organ rejection (terminal). The chronic or minor GVHR is characterized by six phases, namely: 1) a transient phase of aplasia, 2) a repopulation phase, 3) a phase of proliferation and tissue infiltration by lymphoid, presumably immunocompetent cells, 4) a phase of major immunologic injuries, 5) a phase of repair, and 6)a terminal phase with advanced sclerosis and proliferative glomerulonephritis. In acute or major GVHR the disease was manifested by the tissue reactions characteristic of acute organ rejection. Lesions were seen in the kidney, liver, bone marrow, lymph nodes, spleen, thymus, intestine, and skin. In the chronic or minor GVHR, tissue injuries were more widespread, affecting the collagen, vessel walls, adipose tissue, renal glomeruli, heart muscle, fascias of skeletal muscles, lymph nodes, spleen, thymus, bone marrow, intestine, skin, esophageal mucosa, and urinary tract. A pronounced plasma cell proliferation was a striking feature in the minor GVHR. Its evolution coincided with advanced thymic epithelial atrophy. It is suggested that the destruction of thymic epithelium resulted in depletion of suppressor T cells and, consequently, in an unopposed proliferation of plasma cells.

This article has been cited by other articles:

				S. Nusair, R. Or, S. Junadi, G. Amir, and R. Breuer Simultaneous Donor Marrow Cell Transplantation With Reduced Intensity Conditioning Prevents Tracheal Allograft Obliteration in a Bronchiolitis Obliterans Murine Model Chest, December 1, 2005; 128(6): 4024 - 4029. [Abstract] [Full Text] [PDF]

				D. Metcalf, S. Mifsud, L. Di Rago, and W. S. Alexander The lethal effects of transplantation of Socs1-/- bone marrow cells into irradiated adult syngeneic recipients PNAS, July 8, 2003; 100(14): 8436 - 8441. [Abstract] [Full Text] [PDF]

				S. M. Kornblau, I. Stiouf, V. Snell, D. Przepiorka, L. C. Stephens, R. Champlin, and F. C. Marini III Preemptive Control of Graft-versus-Host Disease in a Murine Allogeneic Transplant Model Using Retrovirally Transduced Murine Suicidal Lymphocytes Cancer Res., April 1, 2001; 61(8): 3355 - 3360. [Abstract] [Full Text]

				P. Bobe, K. Benihoud, D. Grandjon, P. Opolon, L. L. Pritchard, and R. Huchet Nitric Oxide Mediation of Active Immunosuppression Associated With Graft-Versus-Host Reaction Blood, August 1, 1999; 94(3): 1028 - 1037. [Abstract] [Full Text] [PDF]

				A. Panoskaltsis-Mortari, D. L. Lacey, D. A. Vallera, and B. R. Blazar Keratinocyte Growth Factor Administered Before Conditioning Ameliorates Graft-Versus-Host Disease After Allogeneic Bone Marrow Transplantation in Mice Blood, November 15, 1998; 92(10): 3960 - 3967. [Abstract] [Full Text] [PDF]

				S. Ehl, J. Hombach, P. Aichele, T. Rulicke, B. Odermatt, H. Hengartner, R. Zinkernagel, and H. Pircher Viral and Bacterial Infections Interfere with Peripheral Tolerance Induction and Activate CD8+ T Cells to Cause Immunopathology J. Exp. Med., March 2, 1998; 187(5): 763 - 774. [Abstract] [Full Text] [PDF]

				G. Shankar, J. Scott Bryson, C. Darrell Jennings, P. E. Morris, and D. A. Cohen Idiopathic Pneumonia Syndrome in Mice after Allogeneic Bone Marrow Transplantation Am. J. Respir. Cell Mol. Biol., February 1, 1998; 18(2): 235 - 242. [Abstract] [Full Text]

				D. Metcalf, S. Mifsud, L. Di Rago, N. A. Nicola, D. J. Hilton, and W. S. Alexander Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1) PNAS, January 22, 2002; 99(2): 943 - 948. [Abstract] [Full Text] [PDF]