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American Journal of Pathology, Vol 97, 315-326, Copyright © 1979 by American Society for Investigative Pathology

REGULAR ARTICLES

Comparative late effects of X-rays and negative pimesons on the mouse kidney

SW Jordan, JM Yuhas, CR Key, KR Hogstrom, JL Butler and MM Kligerman

A system is described for comparing various modalities and fractionation schedules of radiation by means of their long-term morphologic effects upon the mouse kidney. The comparison system utilizes a grading scale for histopathologic changes in which a given histologic grade depends upon meeting defined threshold criteria, rather than quantitation of a particular measurement. Renal tubular alterations served as the basis for comparison, since they appeared more reliably defined than glomerular changes. The radiation dose that induced a specific threshold effect in kidneys from 50% of the animals at 6 months was defined as the effective dose-50%, or ED50.ED50 was found for x-rays and negative pimesons administered in 1, 2, or 5 fractions. From these data, the relative biologic effectiveness (RBE) of negative pi-mesons with respect to x-rays was determined for each fractionation schedule.




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Copyright © 1979 by the American Society for Investigative Pathology.